Search for dissertations about: "Tumour DNA"
Showing result 1 - 5 of 172 swedish dissertations containing the words Tumour DNA.
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1. Salivary gland neoplasms : studies on the cytoskeleton, the secretory apparatus and the nuclear DNA content
Abstract : The heterogeneity of salivary gland neoplasms have made classification and prognostication of these tumours sometimes difficult, and the introduction of techniques, such as enzyme and carbohydrate histochemistry and electron microscopy have only to a certain extent increased our knowledge in these respects. In the present study immunohistochemical methods have been used to identify intermediate filament proteins (IFP) in normal fetal and adult parotid glands, as well as in salivary neoplasms. READ MORE
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2. Structural and Functional Studies of Wilms Tumour Protein - WT1; Novel Insights into Functionality of Zinc Finger Proteins
Abstract : The molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. READ MORE
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3. Specific anti-tumour effects of 6-diazo-5-oxo-L-norleucine (DON) on carcinoid tumour cells
Abstract : Glutamine is essential for cell growth. 6-diazo-5-oxo-L-norleucine (DON) is a rather old anti-tumour drug developed as a glutamine antagonist. Previous clinical trials with DON, not including carcinoid tumours, did not prove convincing. Hence the drug was not further used. READ MORE
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4. Regulation of DNA damage responses by the Myc oncogene : implications for future anti-cancer therapies
Abstract : Myc is a transcription factor frequently found deregulated in human cancer. Cells with deregulated expression of Myc carry a selective advantage against its neighbours due to the fact that Myc-mediated transcription governs crucial cellular events such as proliferation and growth. READ MORE
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5. Functional Characterization of the Yeast Tumour Suppressor Homologue Sro7p
Abstract : Correct targeting of newly synthesized proteins to appropriate domains of the cell membrane is crucial to cellular architecture, polarity and function, making it no surprise that many proteins of the secretory machinery are conserved throughout evolution. This work presents a functional characterisation of the Saccharomyces cerevisiae cell polarity protein and tumour suppressor homologue, Sro7p. READ MORE