Search for dissertations about: "Two-State"

Showing result 1 - 5 of 46 swedish dissertations containing the word Two-State.

  2. 1. Physical Modeling of Protein Folding

    Author : Stefan Wallin; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; relativity; quantum mechanics; classical mechanics; three-helix bundle; similarity measure; Mathematical and general theoretical physics; protein dynamics; protein folding; two-state; Matematisk och allmän teoretisk fysik; thermodynamics; statistical physics; gravitation; klassisk mekanik; kvantmekanik; relativitet; statistisk fysik; termodynamik; Fysicumarkivet A:2003:Wallin;

    Abstract : Sequence-based models for protein folding are developed and tested on peptides with both alpha- and beta-structure, and on small three-helix-bundle proteins. The interaction potentials of the models are minimalistic and based mainly on hydrogen bonding and effective hydrophobicity forces. READ MORE

  4. 2. Protein Folding Studied by Site Directed Mutagenesis

    Author : Tomas Ternström; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Metabolism; Biokemi; metabolism; Biochemistry; Transition state; Activation Barrier; Two-State; Protein Folding; Protein Engineering;

    Abstract : The N-terminal RNA binding domain of U1A has been shown to fold in a two-state process without accumulating any intermediates. U1A has a symmetrically curved chevron plot which seems to result mainly from changes of the transition state. READ MORE

  5. 3. Rate Limiting Factors For Protein Folding

    Author : Maria Berggård Silow; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; kinetic competition; transient aggregation; diffusion control; reconfiguration time; collapse; osmolytes; broad barriers; Hammond behaviour; two-state; U1A; CI2; Proteins; enzymology; Proteiner; enzymologi;

    Abstract : Abstract. This thesis describes factors that are rate limiting for the folding of two small proteins, U1A and CI2 which fold without accumulating intermediates. The [GdnHCl] dependencies of the unfolding- and refolding kinetics of U1A display downward curvatures. READ MORE

  6. 4. Statistical Physics of Protein Folding and Aggregation

    Author : Giorgio Favrin; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Two State; Physics; Fysik; Statistics; operations research; programming; aktuariematematik; programmering; operationsanalys; actuarial mathematics; Statistik; Simulations; Aggregation; Protein Folding; Fysicumarkivet A:2004:Favrin;

    Abstract : The mechanisms of protein folding and aggregation are investigated by computer simulations of all-atom and reduced models with sequence-based potentials. A quasi local Monte Carlo update is developed in order to efficiently sample proteins in the folded phase. READ MORE

  7. 5. First step to a genomic CALPHAD database for cemented carbides : C-Co-Cr alloys

    Author : Zhou Li; Malin Selleby; Jana Pavlu; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; CALPHAD; Einstein model; two-state model; compound energy formalism; thermodynamic description; C-Co-Cr; Teknisk materialvetenskap; Materials Science and Engineering;

    Abstract : CALPHAD (CALculation of PHAse Diagrams) denotes the methodology used to assess thermodynamic data based on experiments as well as on first principles calculations. Essential for this method is the coupling of phase diagram and thermodynamic properties. READ MORE