Search for dissertations about: "Type 2 complications metabolism"

Showing result 1 - 5 of 33 swedish dissertations containing the words Type 2 complications metabolism.

  2. 1. Estrogen and its receptors in adipose tissue from women and men : Associations with age, adiposity and type 2 diabetes

    Author : Fozia Ahmed; Jan Eriksson; Maria J. Pereira; Susanne Hetty; Karin Stenkula; Uppsala University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipose tissue; estrogen; estrogen receptors; menopause; obesity; insulin resistance; type 2 diabetes.;

    Abstract : Obesity and its complications, such as insulin resistance and type 2 diabetes (T2D), are leading causes of morbidity and mortality globally. Adipose tissue is important for whole-body homeostasis, functioning as an energy storage reservoir and an endocrine organ. READ MORE

  4. 2. Pharmacological and genetic manipulation of adipose cell differentiation and metabolism

    Author : Milica Vranic; Maria J. Pereira; Jan Eriksson; Niklas Mejhert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue; adipocyte; type 2 diabetes; CRISP Cas9; FKBP51; CDKN2C; second-generation antipsychotics; glucocorticoids; dopamine; dopamine receptor;

    Abstract : Adipose tissue dysfunction has a pivotal role in the development of obesity and related metabolic complications, such as insulin resistance, cardiovascular disease, and diabetes. The overall aim was to study the consequences of adipose exposure to pharmacological agents, as well as dysregulations in the expression of genes, potentially involved in adipose tissue dysfunction and related metabolic impairments. READ MORE

  5. 3. Protein kinase STK25 is a regulator of hepatic lipid partitioning and whole body metabolism

    Author : Manoj Amrutkar; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NAFLD; NASH; Liver lipid metabolism; Type 2 diabetes; STK25;

    Abstract : In past decade, type 2 diabetes (T2D) and associated metabolic complications have become a major global threat for human health with epidemic increase in incidence. Currently available treatments for T2D have several limitations and side effects making it difficult safely reach adequate metabolic control. READ MORE

  6. 4. Exploring the Grey Zone between Type 1 and Type 2 Diabetes

    Author : Ekaterine Bakhtadze; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : T1D is most common in children and young adults and is characterized by autoimmune destruction of insulin producing pancreatic beta cells, presence of certain risk genotypes such as HLA-DQB1, INS VNTR, PTPN22 and need of insulin for survival. In adults the same situation is often referred to as Latent Autoimmune Diabetes in Adults (LADA), with age at onset after 35 years and non-insulin requiring at least for 6 month after diagnosis. READ MORE

  7. 5. Progressive elements in type 2 diabetes, studies on secondary failure and diabetic complications

    Author : Lars Kärvestedt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Diabetes is a progressive disease with late complications, one of the most common being diabetic neuropathy (DN). DN can lead to serious complications and accounts for more hospitalization and higher costs than all other complications of diabetes combined. READ MORE