Search for dissertations about: "Type 4 Secretion Systems"
Showing result 1 - 5 of 27 swedish dissertations containing the words Type 4 Secretion Systems.
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1. Exploring the mechanistic details of Gram-positive Type 4 Secretion Systems
Abstract : Hospital acquired (i.e. nosocomial) infections and antibiotic resistance are large issues in the world today, with about 1.3 million people estimated to have died from antibiotic resistant infections in 2019 alone, and these problems are on the rise. READ MORE
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2. Type 2 Diabetes Genes Contributing to Insulin Secretion Defects
Abstract : Type 2 diabetes is caused by a combination of environmental and inherited factors influencing the progression of insulin resistance and impaired insulin secretion leading to chronically elevated blood glucose levels. The aim of this thesis was to functionally and genetically characterise the species-conserved diabetes locus Niddm1i of the GK rat encoding hyperglycaemia and defect insulin secretion. READ MORE
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3. Exploring Positional and Functional Candidate Genes for Type 2 Diabetes
Abstract : Type 2 diabetes (T2D) is a complex, metabolic disorder characterized by hyperglycaemia because of defects in insulin secretion and sensitivity. The rapid increase in T2D is likely to reflect the influence of both genetic and environmental factors in disease development. However, the genetic aetiology of T2D remains largely unknown. READ MORE
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4. Pathogenesis of type 2 diabetes -role of defects in insulin secretion and insulin sensitivity
Abstract : Type 2 diabetes is characterised by defects in insulin sensitivity, insulin secretion and increased endogenous glucose production. The relative contribution of each of these defects remains controversial. READ MORE
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5. Characterization of Impaired Glucose Tolerance - Insulin Sensitivity, Islet Function and Metabolic Risk Factors
Abstract : This thesis presents a three-year prospective study on metabolic characteristics of impaired glucose tolerance (IGT) and the regulation of insulin sensitivity versus islet function in relation to changes in glucose tolerance. 108 non-diabetic women aged 57-58 years were randomly selected from a population of women born in 1935 with a high prevalence of IGT. READ MORE