Search for dissertations about: "Type III secretion system"

Showing result 1 - 5 of 76 swedish dissertations containing the words Type III secretion system.

  2. 1. Coordinating type III secretion system biogenesis in Yersinia pseudotuberculosis

    Author : Jyoti Mohan Gurung; Matthew S Francis; Maria Fällman; Dirk Linke; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia pseudotuberculosis; type III secretion system; YscX; YscY; YopN; TyeA; secretion signal; N-terminal region; site-directed mutagenesis; molekylärbiologi; Molecular Biology; mikrobiologi; Microbiology;

    Abstract : Various Gram-negative bacteria utilize type III secretion system (T3SS) to deliver effectors into eukaryotic host cells and establish mutualistic or pathogenic interactions. An example is the Ysc-Yop T3SS of pathogenic Yersinia species. READ MORE

  4. 2. Multiple functions of YopN in the Yersinia pseudotuberculosis type III secretion system : from regulation to in vivo infection

    Author : Sarp Bamyaci; Åke Forsberg; Edouard Galyov; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Type III secretion system; Yersinia; YopN; virulence; phagocytosis; mouse infection; secretion kinetics;

    Abstract : The type 3 secretion systems (T3SSs) are virulence mechanisms used by various Gram-negative bacteria to overcome the host immunity. They are often target-cell contact induced and activated. Activation results in targeting of virulence effector substrates into host cells. READ MORE

  5. 3. Chemical attenuation of bacterial virulence : small molecule inhibitors of type III secretion

    Author : Anna Kauppi; Mikael Elofsson; Anders Karlén; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; virulence; type III secretion; T3SS inhibitors; Yop; SMD; QSAR; screening; Yersinia pseudotuberculosis; Organic chemistry; Organisk kemi;

    Abstract : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. READ MORE

  6. 4. Type III Secretion Mediated Translocation of Effector Exoenzymes by Pseudomonas aeruginosa

    Author : Charlotta Sundin; Åke Forsberg; Anthony Pugsley; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Pseudomonas aeruginosa; type III secretion system; ExoS; ExoT; PcrV; PcrG; PopB; PopD; PopN; type IV pili; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : .... READ MORE

  7. 5. Virulence mechanisms of pathogenic Yersinia : aspects of type III secretion and twin arginine translocation

    Author : Moa Lavander; Åke Forsberg; George Salmond; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Yersinia pestis; Yersinia pseudotuberculosis; bacterial pathogenesis; type III secretion; twin arginine translocation; virulence mechanisms; YscU; YscP; YscF; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The pathogenic bacteria Yersinia pestis and Y. pseudotuberculosis are related to the degree where the former is considered a subspecies of the latter, and still they cause disease of little resemblance in humans. Y. pestis is the causative agent of lethal bubonic and pneumonic plague, while Y. READ MORE