Search for dissertations about: "Type-I collagen"

Showing result 1 - 5 of 65 swedish dissertations containing the words Type-I collagen.

  2. 1. Type I collagen synthesis in connective tissues : studies on cultured cells and tissues

    Author : Mikael Ivarsson; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 2. Osteogenesis Imperfecta : Genetic and Therapeutic Studies

    Author : Katarina Lindahl; Östen Ljunggren; Andreas Kindmark; Carl-Johan Rubin; David Sillence; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; OI; BMD; Genotype; Phenotype; Pharmaco-genetics; Bisphosphonate; Therapy; Gene-therapy; Mutation; Collagen; Collagen type I; Allele-specific silencing; siRNA; RNAi; COL1A1; COL1A2; Stroke; C-propeptide; Mineralization; Heterozygous disadvantage; Genetics; Genetik; Medicin; Medicine; Medical Genetics; Medicinsk genetik;

    Abstract : Osteogenesis imperfecta (OI) is a heterogeneous disease of connective tissue, the cardinal symptom being fractures and severity ranging from mild to lethal. Dominant mutations in collagen I, encoded by COL1A1 and COL1A2, cause >90% of cases. READ MORE

  5. 3. The role of stroma-derived substances in breast cancer progression and their function as tumour markers

    Author : Malin Jansson; Malin Sund; Daniel Öhlund; Ola Billing; Emma Niméus; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; perlecan; type IV collagen; type I collagen; extracellular matrix; tumour biomarkers; Surgery; kirurgi;

    Abstract : Background: In 2020, more than 2,260,000 women were diagnosed with breast cancer. Most patients are cured with surgery and adjuvant treatment, but despite that, approximately 700,000 women die of the disease every year. The historical focus on breast cancer progression has been on the malignant epithelial cell. READ MORE

  6. 4. The role of leucine-rich repeat glycoproteins/proteoglycans in the assembly of collagen matrices

    Author : Liz Svensson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reumatologi; muskelsystem; Skelett; decorin; Collagen; fibromodulin; extracellular matrix; lumican; collagen fibrillogenesis; Skeleton; rheumatology locomotion; muscle system; Biochemistry; Biokemi; Metabolism;

    Abstract : The properties of different connective tissues depend on the synthesis and assembly of macromolecular structures composed of collagen and other extracellular matrix components. Mechanisms modulating these events play important roles in the formation of a functional tissue. READ MORE

  7. 5. Interactions between the stroma and thyroid epithelial cells of normal and malignant origin

    Author : Thérèse Dahlman; Uppsala universitet; []
    Keywords : Medical sciences; Thyroid gland; carcinoma; collagen type I; EGF; TGF-b1; interaction; integrins; E-cadherin; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Endocrine and locally produced factors as well as interactions between epithelial cells and the stroma important in the control of growth and function of the thyroid gland. In this study, the effects of, and mechanism(s) for, such cross-talk under some normal and pathological conditions were investigated. READ MORE