Search for dissertations about: "U0126"
Showing result 1 - 5 of 11 swedish dissertations containing the word U0126.
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1. Hyperglycemia and Focal Brain Ischemia : Clinical and Experimental Studies
Abstract : Diabetes is a major risk factor for ischemic stroke and is associated with increased mortality. Additionally, hyperglycemia, a common complication in acute stroke, is associated with poor outcome. READ MORE
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2. Delayed Cell Death after Traumatic Brain Injury : Role of Reactive Oxygen Species
Abstract : Traumatic brain injury (TBI) is a leading cause of death and disability TBI survivors often suffer from severe disturbances of cognition, memory and emotions. Improving the treatment is of great importance, but as of yet no specific neuroprotective treatment has been found. READ MORE
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3. Reversal of thyroid dedifferentiation and an invasive phenotype by small molecule kinase inhibitors: an experimental study on normal and malignant cells
Abstract : Refractoriness to I-131 in dedifferentiated thyroid cancer is a great concern that restricts radioiodine therapy. There is also a lack of knowledge in understanding the mechanisms leading to repressed sodium iodide symporter (NIS) expression and impaired iodide uptake in tumor cells. READ MORE
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4. The role of the MAP- and SAP- kinase pathways in the survival, proliferation and death of Schwann cells of the injured sciatic nerve
Abstract : This thesis concerns alterations in signal transduction in Schwann cells as a response to nerve injury as well as their survival, proliferation and death. Enzymes and transcription factors belonging to the mitogen activated protein kinase (MAPK) and the stress activated protein kinase (SAPK) pathways were studied. READ MORE
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5. A Path for Improving Stroke Recovery. Effects of MEK-ERK1/2 Inhibition
Abstract : The present thesis aimed to shed more light on the notion of acute inhibition of extracellular-signal regulated kinase (ERK)1/2 pathway as a treatment to improve stroke recovery. Stroke is a major cause of death and long-term disability worldwide, classified as ischemic or hemorrhagic. READ MORE