Search for dissertations about: "U1"

Showing result 1 - 5 of 19 swedish dissertations containing the word U1.

  2. 1. Understanding the Noise : Spliceosomal snRNA Profiling

    Author : Lei Liu Conze; Anders Virtanen; Lars Wieslander; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ncRNA; snRNA; U1; splice site; alternative splicing; high-throughput sequencing; 454; SNP; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : The concept of the gene has been constantly challenged by new discoveries in the life sciences. Recent challenging observations include the high frequency of alternative splicing events and the common transcription of non-protein-coding-RNAs (ncRNAs) from the genome. The latter has long been considered noise in biological systems. READ MORE

  4. 2. Computational Approaches to the Identification and Characterization of Non-Coding RNA Genes

    Author : Pontus Larsson; Anders Virtanen; Leif Kirsebom; Stephen Mount; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ncRNA; snRNA; U1; splice site; alternative splicing; Dictyostelium; nucleotide composition; partial sums; Bioinformatics; Bioinformatik;

    Abstract : Non-coding RNAs (ncRNAs) have emerged as highly diverse and powerful key players in the cell, the range of capabilities spanning from catalyzing essential processes in all living organisms, e.g. protein synthesis, to being highly specific regulators of gene expression. READ MORE

  5. 3. Autoantigenic properties of the U1-70K protein

    Author : Elisabet Welin Henriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : U1-70K protein; ribonucleoproteins; autoantigens; autoantibodies; epitopemapping; connective tissue disease; species specificity; cross reactions; amino acidsequence; recombinant proteins; mutagenesis;

    Abstract : Patients with the autoimmune diseases systemic lupus erythematosus and mixed connective tissue disease produce autoantibodies directed towards specific groups of cellular constituents in their own body. Two of the targeted antigens are denoted Sm and RNP, and consist of distinct collections of splicing associated RNA-protein complexes. READ MORE

  6. 4. Autoantibodies in healthy blood donors, rheumatic and autoimmune liver diseases

    Author : Awais Ahmad; Christopher Sjöwall; Charlotte Dahle; Stergios Kechagias; Marco W.J. Schreuers; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Autoimmunity is a common phenomenon where the immune system recognises the body's own tissues. Autoimmunity can lead to disease if tissue damage occurs. Autoimmune diseases affect 5–10% of the global population and in many of these autoantibodies can be detected. The autoantibodies can be detected with several different methods. READ MORE

  7. 5. Role of collagen type II specific antibodies in arthritis

    Author : Estelle Bajtner; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serologi; transplantation; serology; Immunology; tolerance; collagen type II; CIA; B cell epitope; antibody; arthritis; Immunologi;

    Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory disease resulting in destruction of cartilage and bone. The role of the B cells in RA pathogenesis clearly involves autoantibodies. Collagen type II (CII)-specific antibodies have been identified in RA synovium and synovial fluid. READ MORE