Search for dissertations about: "UGT enzymes"

Found 4 swedish dissertations containing the words UGT enzymes.

  2. 1. In vivo Pharmacokinetic Interactions of Finasteride and Identification of Novel Metabolites

    Author : Anna Lundahl; Hans Lennernäs; Dennis A Smith; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug-drug interactions; herb-drug interactions; pharmacokinetics; metabolism; CYP3A4; hydroxylation; glucuronidation; UGT enzymes; mass spectrometry; biliary excretion; urinary excretion; finasteride; PHARMACY; FARMACI;

    Abstract : The general aim of this thesis was to improve the understanding of the in vivo pharmacokinetics and, in particular, the metabolism of finasteride, a 5α-reductase inhibitor used in the treatment of enlarged prostate glands and male pattern baldness. CYP3A4 has been identified as the major enzyme involved in the sequential metabolism of finasteride to ω-OH finasteride (M1) and ω-COOH finasteride (M3). READ MORE

  4. 2. Human liver in vitro models for evaluation of drug metabolism and disposition

    Author : Malin Darnell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The administrated dose of a drug is adjusted to give a therapeutic effect in patients without causing side-effects or toxicity. Cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT) enzymes, uptake and efflux transporters and nuclear receptors regulating these enzymes, expressed in the liver and in other tissues, are all important players in drug metabolism, disposition and elimination. READ MORE

  5. 3. Clinical Pharmacogenetics of Olanzapine : with Focus on FMO Gene Polymorphisms

    Author : Mao Mao Söderberg; Marja-Liisa Dahl; Maria Gabriella Scordo; Inger Johansson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; olanzapine; pharmacogenetics; drug metabolism; schizophrenia; therapeutic drug monitoring; FMO1; FMO3; CYP1A2; UGT1A4; Clinical Pharmacology; Klinisk farmakologi;

    Abstract : Pharmacogenetics is the study of variability in drug response attributed to genetic variation. Olanzapine (OLA) is a widely used antipsychotic drug for schizophrenia treatment. The pharmacokinetics of OLA display large inter-individual variation leading to multiple-fold differences in drug exposure between patients at a given dose. READ MORE

  6. 4. Controlling Fusarium Head Blight in oat

    Author : Alfia Khairullina; Tillämpad biokemi; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; FHB; oat; UDP-glucosyltransferase; deoxynivalenol; mycotoxins; biocontrol; Clonostachys rosea; Fusarium head blight; Fusarium graminearum; endophytes;

    Abstract : Oats (Avena sativa) is a versatile crop grown worldwide for animal feed and human consumption. Humanoat consumption has recently risen due to its various health benefits. However, oats are susceptible toFusarium head blight (FHB) caused by various Fusarium fungi. FHB reduces yield and leads to mycotoxinaccumulation. READ MORE