Search for dissertations about: "USP9X"

Found 2 swedish dissertations containing the word USP9X.

  2. 1. Identifying Essential Deubiquitinase Interactions and Targeting Protein Ubiquitination in Cancer

    Author : Johannes Gubat; Padraig D´arcy; Stig Linder; Maria Turkina; Per Lindahl; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Deubiquitinase; b-AP15; Ubiquitin-proteasome system;

    Abstract : Cancer is the second leading cause of death globally and is one of the most pressing health issues today. While significant advances have been made in cancer treatment, drug resistance and toxicity remain formidable obstacles to successful therapy. Thus, there is a need to find novel targets that pave the way for new cancer therapeutics. READ MORE

  4. 2. Modulation of the deubiquitnating system during lymphoid cell activation and viral infection

    Author : Ulrika Rolén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The family of ubiquitin-specific proteases (USPs) removes ubiquitin from its conjugates and regulates the production and recycling of ubiquitin. USPs are thereby critically involved in the control of important functions such as cell growth, differentiation and apoptosis. Increasing evidence implicates USPs deregulation in malignant transformation. READ MORE