Search for dissertations about: "Ubiquitin"

Showing result 11 - 15 of 194 swedish dissertations containing the word Ubiquitin.

  2. 11. Development of NMR methods for studies of dynamics and structure : applications to motilin, Alzheimer β-peptide and ubiquitin

    Author : Peter Damberg; Ad Bax; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik;

    Abstract : NMR spin relaxation was used to study structure and dynamics of two biologically important peptides.The first case concerns the three-dimensional structure of the 22 amino acid residue peptide hormone motilin in the presence of SDS micelles, which mimic a biomembrane environment. READ MORE

  4. 12. The role of the ubiquitin-proteasome system in neurodegenerative disorders

    Author : Lisette Gerridina Gezina Catharina Verhoef; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Degradation; green fluorescent protein GFP ; neurodegeneration; polyglutamine; proteasome; UBB 1; ubiquitin;

    Abstract : Neurodegenerative disorders are a heterogeneous group of clinically and pathologically diverse diseases. The diseases are characterised by selective loss of neurons. in specific regions of the brain. The result is disruption of motor, sensory or cognitive systems, leading to severe disability of the patients. READ MORE

  5. 13. Modulation of nuclear receptor signaling by RBR ubiquitin ligases

    Author : Nina Gustafsson Sheppard; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nuclear receptors (NRs) constitute a superfamily of transcription factors and play important roles in physiology. Transcriptional regulation by NRs can be modulated through interactions with various coregulators that activate or repress transcription through mediating receptor and chromatin modifications as well as communicating with the general transcription factor machinery. READ MORE

  6. 14. Functional studies of the ubiquitin proteasome system using GFP based reporters

    Author : Kristina Lindsten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ubiquitin; proteasome; green fluorescent protein GFP ; degradation; inhibitor; Gly-Ala repeat; neurodegencration; poly-Gln aggregates.;

    Abstract : Ubiquitin-dependent proteasomal degradation is of paramount importance for cellular processes such as cell cycle progression, transcriptional regulation, apoptosis and disposal of misfolded and aberrant proteins. Moreover the ubiquitin-proteasome system is the main producer of peptides used by major histocompatibility complex class 1 for antigen presentation. READ MORE

  7. 15. Regulation of the ubiquitin-proteasome system : characterization of viral and cellular stabilization signals

    Author : Stijn Heessen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Epstein-Barr virus EBV ; glycine-alanine GA repeat; green fluorescent protein GFP ; degron; proteasome; Rad23; ubiquitin; ubiquitin- associated UBA domain;

    Abstract : The ubiquitin-proteasome system plays a fundamental role in virtually every cellular process. Degradation of endogenous proteins by this system is the major source for antigenic peptides that are presented to MHC class I-restricted cytotoxic T cells. READ MORE