Search for dissertations about: "Ubiquitin"

Showing result 21 - 25 of 193 swedish dissertations containing the word Ubiquitin.

  2. 21. Evaluation of the Endo-Lysosomal System and the Ubiquitin-Proteasome System in Neurodegenerative Diseases

    Author : Simon Sjödin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Parkinson’s disease; frontotemporal dementia; dysfunctional proteostasis; cerebrospinal fluid; mass spectrometry;

    Abstract : Neurodegeneration is the process of neuronal cell loss where the symptoms will reflect the regions affected. Neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s disease (PD) and frontotemporal dementia (FTD) are all characterised by an accumulation of protein aggregates suggesting impaired production or turnover of these proteins. READ MORE

  4. 22. Regulation of Hsp70 function by nucleotide-exchange factors

    Author : Naveen Kumar Chandappa Gowda; Claes Andréasson; Gary Jones; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Heat shock proteins Hsps ; Hsp70; Molecular chaperones; Nucleotide-exchange factors NEFs ; Protein quality control PQC ; Proteostasis; Ubiquitin-proteasome system; Cell Biology; cellbiologi;

    Abstract : Protein folding is the process in which polypeptides in their non-native states attain the unique folds of their native states. Adverse environmental conditions and genetic predisposition challenge the folding process and accelerate the production of proteotoxic misfolded proteins. READ MORE

  5. 23. Expression and function of vascular estrogen receptors alpha and beta

    Author : Min Liang; Kärlfysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; secreting systems; diabetologi; diabetology; Endokrinologi; sekretion; ubiquitin-proteasome pathway; MIP-2; MCP-1; iNOS; estrogen receptor knockout; estrogen receptor; aorta; estrogen;

    Abstract : Estrogen receptors (ER) are expressed not only in classical target organs for estrogen like breast and uterus, but also in male reproductive system as well as in non-reproductive organs such as brain, liver and bone. The functions of ER are quite well known in reproductive organs but less information is available regarding their function in vascular tissue. READ MORE

  6. 24. Function and targets of the Urm1/Uba4 conjugation machinery in Drosophila melanogaster

    Author : Behzad Khoshnood; Caroline Grabbe; Tor Erik Rusten; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Urm1; Uba4; MOCS3; Tax; HTLV; Posttranslational modification; ubiquitin-like modifiers; UBL; PTM; JNK; neuromuscular junctions; signaling; molekylärbiologi; Molecular Biology;

    Abstract : Posttranslational modification (PTM) of proteins is essential to maintain homeostasis and viability in all eukaryotic cells. Hence, besides the sequence and 3D folding of a polypeptide, modification by multiple types of PTMs, ranging from small molecular groups to entire protein modules, adds another layer of complexity to protein function and regulation. READ MORE

  7. 25. Proteostasis and Aging in Saccharomyces cerevisiae - The role of a Peroxiredoxin

    Author : Sarah Hanzén; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Aging; Caloric restriction; Oxidative stress; Peroxiredoxins; Proteostasis; Protein aggregates; Ubiquitin-proteasome system;

    Abstract : Aging is characterized by a progressive decline in physiological functions that limits biological processes, increases the risk of disease, and ultimately leads to death. At the cellular level, aging is associated with accumulation of damaged components, including proteins, indicating that protein homeostasis (or proteostasis) fails to maintain the integrity and functionality of the proteome as cells age. READ MORE