Search for dissertations about: "Ulf Bredberg"
Found 3 swedish dissertations containing the words Ulf Bredberg.
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1. Validation of a new method for estimation of drug absorption : computer simulations and in vivo applications
Abstract : .... READ MORE
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2. Development of Methods for Assessing Unbound Drug Exposure in the Brain : In vivo, in vitro and in silico
Abstract : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. READ MORE
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3. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination
Abstract : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. READ MORE