Search for dissertations about: "Ulrika Wählby"

Found 1 swedish dissertation containing the words Ulrika Wählby.

2. 1. Methodological Studies on Covariate Model Building in Population Pharmacokinetic-Pharmacodynamic Analysis

   Author : Ulrika Wählby; Thomas Ludden; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Abstract : Population pharmacokinetic (PK) – pharmacodynamic (PD) modelling, using nonlinear mixed effects models, is increasingly being applied to obtain PK-PD information in drug development. Covariate modelling, the establishment of relationships between model parameters and patient characteristics, is undertaken to explain PK-PD variability and facilitate dose adjustment decisions, and is consequently an important objective of population PK-PD. READ MORE