Search for dissertations about: "Uncoupling Protein-2"

Showing result 1 - 5 of 13 swedish dissertations containing the words Uncoupling Protein-2.

  2. 1. The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy

    Author : Malou Friederich Persson; Fredrik Palm; Richard K. Porter; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; mitochondria; Uncoupling Protein-2; Adenosine Nucleotide Transporter; uncoupling; diabetes; diabetic nephropathy; db db; dinitrophenol; Coenzyme Q10; oxygen; rats; mice; Physiology; Fysiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Diabetes is closely associated with increased oxidative stress, especially originating from the mitochondria. A mechanism to reduce increased mitochondria superoxide production is to reduce the mitochondria membrane potential by releasing protons across the mitochondria membrane. READ MORE

  4. 2. Molecular mechanisms of weight regulation in obesity and chronic renal failure with special reference to leptin and uncoupling protein 2

    Author : Louise Nordfors; Karolinska Institutet; Karolinska Institutet; []
    Keywords : adipose tissue; BMI; chronic renal failure CRF ; gene expression; in situ hybridization; leptin; obesity; peritoneal dialysis PD ; single nucleotide polymorphism SNP ; UCP2; UCP2-polymorphism;

    Abstract : Obesity, which increases the risk of developing serious medical disorders, such as cardiovascular disease and diabetes, is threatening to become a global epidemic, meaning escalating healthcare costs for society and reduced quality of life for the individual. Thus, there is a large unmet need for improved preventive strategies and effective treatments. READ MORE

  5. 3. Enterostatin - target proteins and intracellular mechanisms. Function in food intake and energy metabolism

    Author : Karin Berger; Molekylär endokrinologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; energy metabolism; insulin; uncoupling protein; beta-casomorphin; opiate; SK-N-MC; INS-1; Medicin människa och djur ; Medicine human and vertebrates ; fat intake; F1F0-ATP synthase; appetite; enterostatin; satiety; obesity;

    Abstract : Hunger and satiety are the results of complex neural events that involve several neurotransmitters and peptides. Enterostatin is an appetite-regulating peptide released in the intestine in response to fat ingestion. Enterostatin specifically decreases fat intake, but has also metabolic effects like inhibition of insulin secretion. READ MORE

  6. 4. Peocolipase and enterostatin- Functions during high-fat feeding

    Author : Catarina Rippe; Cellulär biomekanik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; high-fat diet; obesity; lipase; uncoupling protein; procolipase; enterostatin; Medicin människa och djur ;

    Abstract : Enterostatin is a peptide formed in the stomach and intestine during the activation of pancreatic/gastric procolipase. Procolipase is a necessary cofactor for lipase. These two proteins contribute to the breakdown of dietary triglycerides in the intestine. READ MORE

  7. 5. Experimental Traumatic Brain Injury and Cell Death - in vivo and in vitro aspects

    Author : Gustav Mattiasson; Sektion IV; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurofysiologi; neuropsychology; Neurology; uncoupling protein; mitochondrial permeability transition; cerebral blood flow; functional outcome; cell death; mitochondria; hippocampus; preconditioning; trauma; Brain; ischemia; neuropsykologi; Neurologi; neurophysiology;

    Abstract : Traumatic and ischemic brain damage are major causes of disability and death. While much effort has been spent on developing pharmacological treatments for these conditions, no neuroprotective drugs are in clinical use. READ MORE