Search for dissertations about: "Upregulation"

Showing result 11 - 15 of 530 swedish dissertations containing the word Upregulation.

  2. 11. Regulation of the pro-apoptotic protein Bim by T cell receptor triggering in human T cells

    Author : Elena Sandalova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Bim; Apoptosis; Mitochondria; CTLs; AICD; TCR activation;

    Abstract : Bim is a significant pro-apoptotic member of Bcl-2 family of proteins; it is proved to be an important regulator of apoptosis: over the years it has been shown to play a pivotal role for the development and maintenance of homeostasis in many cellular systems and tissues. The Bcl-2 family of proteins is a group of key regulators of the mitochondrial, or intrinsic, pathway of apoptosis. READ MORE

  4. 12. Mechanisms of dendritic cell maturation induced by intracellular bacteria infection

    Author : Miguel A. Tam; Göteborgs universitet; []
    Keywords : Listeria; Salmonella; dendritic cells; maturation; MyD88; IFN-? ?;

    Abstract : Dendritic cells (DCs) are essential for the development of an immune response against pathogens such as Listeria monocytogenes and Salmonella typhimurium. This is mostly because of their unique capacity to stimulate naïve T cells. READ MORE

  5. 13. Pituitary Adenylate Cyclase Activating Peptide (PACAP): An Experimental Study On the Expression and Regulation in the Peripheral Nervous System

    Author : Kristian Moller; Neuroendokrin cellbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytokemi; histokemi; Histologi; vävnadskultur; Histology; cytochemistry; histochemistry; tissue culture;

    Abstract : This thesis deals with PACAP and PACAP type-1 receptors in the sensory and autonomic parts of the peripheral nervous system. In the rat, PACAP is expressed in small-sized sensory neurons and in C-fibers. READ MORE

  6. 14. Spinal motoneurones and the bulbospinal serotonininergic system in aged rats with behavioral deficits

    Author : Hans Johnson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : aging; behavior; immunohistochemistry; in situ hybridisation; motoneuron; CGRP; axotorny; GAP-43; neurotrophin receptors; degeneration; axon dystrophy; 5HT TRH; SP; 5HLkA; AADC; serotonintransporter protein; fluoxetine; L-5-HTP;

    Abstract : The expression of neuropeptides, growth-related proteins and neurotrophin receptors were studied in motoneurons of young adult rats and in aged rats with symptoms of neuromuscular incapacities. Also studied were aging-related changes in the descending serotoninergic (5HT) bulbospinal system which constitutes a major afferent pathway to spinal motoneurons. READ MORE

  7. 15. Stroke, Sex and Vascular Receptor Changes in the Brain

    Author : Hilda Ahnstedt; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endothelin receptors; Cerebral ischemia; sex; estrogen; progesterone; sex differences; human cerebral arteries; endothelin-1; angiotensin II; middle cerebral artery occlusion; extra-cellular signal regulated kinase 1 and 2;

    Abstract : Stroke is a severe cerebrovascular disease in which the neuronal tissue and vasculature of the brain undergo ischemia-evoked alterations. We have demonstrated an increased expression of cerebrovascular contractile receptors in the brain. This is hypothesized to mitigate cerebral blood flow and exacerbate tissue damage after stroke. READ MORE