Search for dissertations about: "Upregulation"

Showing result 21 - 25 of 530 swedish dissertations containing the word Upregulation.

  2. 21. Effect of Hyaluronan-activation of CD44 on Cell Signaling and Tumorigenesis

    Author : Lingli Li; Paraskevi Heldin; Raija H. Tammi; Uppsala universitet; []
    Keywords : Biomedicine; Hyaluronan; CD44; growth factors; chemokines; tumorigenesis; wound healing; cell signaling; Biomedicin;

    Abstract : Hyaluronan (HA), a structural component in the extracellular matrix (ECM), has been recognized as a signaling molecule. It is important during various biological activities such as embryogenesis, angiogenesis, wound healing and tumor progression. READ MORE

  4. 22. Importance of Hyaluronan-CD44 Signaling in Tumor Progression : Crosstalk with TGFβ and PDGF-BB Signaling

    Author : Helena Porsch; Paraskevi Heldin; Véronique Orian-Rousseau; Uppsala universitet; []
    Keywords : extracellular matrix; growth factor; hyaluronan synthase; hyaluronidase; epithelial-mesenchymal transition; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : In order for solid tumors to metastasize, tumor cells must acquire the ability to invade the surrounding tissue and intravasate into blood- or lymph vessels, survive in the circulation and then extravasate at a distant site to form a new tumor. Overexpression of the glycosaminoglycan hyaluronan, and its adhesion receptor CD44, correlate with breast cancer progression. READ MORE

  5. 23. On keratin mutations in epidermolytic hyperkeratosis and the regulation of keratin expression by retinoids

    Author : Marie Virtanen; Uppsala universitet; []
    Keywords : Medical sciences; EHK; keratin; retinoids; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Dermatology and Venerology; dermatologi och venereologi;

    Abstract : Epidermolytic hyperkeratosis is a rare inherited disease of the skin caused by a dominant-negative mutation in keratin 1 (K1) or 10 (K10). Keratins are the major structural protein in epidermis and mutations causes instability of intermediate filament and keratinocyte fragility. READ MORE

  6. 24. Gene environment-interaction and cardiovascular phenotype in obesity and diabetes

    Author : Shafaat Hussain; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Although a large body of evidence supports the notion that genes determine cardio-metabolic traits and outcomes, the non-genetic regulation of these events has recently gained increasing attention. Plastic chemical modifications of DNA-histone complexes defined epigenetic changes regulate gene expression by modifying chromatin accessibility to transcription factors. READ MORE

  7. 25. Characterisation of eosinophil activity markers : relation to allergic inflammation and apoptosis

    Author : Anna Nopp; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : An allergic inflammation is characterised by many different factors, among which eosinophils and the release of their granule content e.g. eosinophilic cationic protein (ECP) constitute main features. READ MORE