Search for dissertations about: "Utvecklings- och regenerativ neurobiologi"

Showing result 6 - 9 of 9 swedish dissertations containing the words Utvecklings- och regenerativ neurobiologi.

  2. 6. Directing and Dissecting the Fate of Dopaminergic Neurons - Multiple Avenues towards Cell Replacement Therapy in Parkinson's Disease

    Author : Sara Nolbrant; Utvecklings- och regenerativ neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopaminergic neurons; Cell replacement therapy; Parkinson s disease; Human pluripotent stem cells; Cell differentiation; Direct neuronal reprogramming; glial progenitors; midbrain development;

    Abstract : .... READ MORE

  4. 7. Exploring Patient-Specific Cell Replacement Therapy for Parkinson's Disease

    Author : Shelby Shrigley; Utvecklings- och regenerativ neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopaminergic neurons; Parkinson s disease; cell replacement therapy; cellular reprogramming; alpha-synuclein;

    Abstract : Parkinson’s disease (PD) affects over six million people worldwide and is characterised by the progressive loss of dopaminergic (DA) neurons in the substantia nigra, accumulation of pathological alpha-synuclein (αSyn), and inflammation in the brain. This leads to motor impairments including rigidity, akinesia, bradykinesia, resting tremor, and postural instability. READ MORE

  5. 8. Cell Replacement Therapy for Parkinson's Disease: Potential for Circuitry Repair

    Author : Tiago Cardoso; Utvecklings- och regenerativ neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rabies-based tracing; Parkinson s disease cell therapy; Cell Replacement Therapy; Human embryonic stem cells; Dopamine neuron; Synaptic integration; circuitry repair;

    Abstract : The derivation of dopamine neurons from human embryonic stem cells (hESCs) now offers a promising alternative to fetal tissue for cell replacement therapy (CRT) in Parkinson´s disease (PD). Using the appropriate chemical cues in vitro, hESCs can be patterned towards bona-fide ventral midbrain (VM) DA neurons that survive, reinnervate, release DA and provide functional recovery when transplanted into rodent and non-human primate models of PD. READ MORE

  6. 9. Cell reprogramming as a way to produce new functional neurons

    Author : Maria Pereira; Utvecklings- och regenerativ neurobiologi; []
    Keywords : Cell reprogramming; brain repair; cell therapy; induced neurons; in vitro reprogramming; in vivo reprogramming; Parkinson s disease;

    Abstract : .... READ MORE