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Showing result 1 - 5 of 6 swedish dissertations matching the above criteria.

2. 1. Mutational effects on protein structure and function

   Author : Jonas Carlsson; Persson Bengt; Uwe Sauer; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mutation; prediction; phenotypes; homology model; virtual screening; molecular dynamics; amyloid; cancer; membrane protein; Bioinformatics; Bioinformatik;

   Abstract : In this thesis several important proteins are investigated from a structural perspective. Some of the proteins are disease related while other have important but not completely characterised functions. READ MORE

4. 2. X-ray characterization of PaPheOH, a bacterial phenylalanine hydroxylase

   Author : Fredrik Ekström; Uwe H. Sauer; Edward Hough; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; PaPheOH; PheOH; PAH; phhA; phenylalanine hydroxylase; protein crystallography; a-actinin; microcrystal; ABD; CH-domain; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

   Abstract : Many human diseases are associated with the malfunction of enzymes in the aromatic amino acid hydroxylase family, e.g. phenylketonuria (PKU), hyperphenylalaninemia (HPA), schizophrenia and Parkinson's disease. READ MORE

5. 3. Structural biology studies of thylakoid lumen proteins required for photosystem II assembly and function

   Author : Roland Locmelis; Uwe Sauer; Wolfgang Schröder; Inger Andersson; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; structural biology; x-ray crystallography; cloning; protein expression; HCF136; LPA19; MPH2; Prx6; photosynthesis; thylakoid lumen PSII;

   Abstract : Little is known about the structures and functions of thylakoid lumen proteins. However, some of these proteins have an essential role in photosynthesis. READ MORE

6. 4. Deciphering control of Mechano-Transcription Activators of σ54-RNA polymerase

   Author : Henrik Seibt; Victoria Shingler; Uwe H. Sauer; Ray Dixon; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transcriptional regulation; P. putida; V. cholerae; AAA ; bEBP; B-linker; DmpR; Phenol catabolism; VCA0117; Type VI secretion; molekylärbiologi; Molecular Biology;

   Abstract : To survive and proliferate, bacteria have to respond to a plethora of fluctuating signals within their habitats. Transcriptional control is one crucial entry point for such signal-responsive adaption responses. READ MORE

7. 5. Structural Information and Hidden Markov Models for Biological Sequence Analysis

   Author : Jeanette Tångrot; Bo Kågström; Uwe H. Sauer; Erik Sonnhammer; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; HMM; structure alignment; protein structure; secondary structure; remote homologue; annotation; domain family; protein family; protein superfamily; protein fold recognition; Bioinformatics; Bioinformatik;

   Abstract : Bioinformatics is a fast-developing field, which makes use of computational methods to analyse and structure biological data. An important branch of bioinformatics is structure and function prediction of proteins, which is often based on finding relationships to already characterized proteins. READ MORE