Search for dissertations about: "Véronique Chotteau"

Showing result 1 - 5 of 6 swedish dissertations containing the words Véronique Chotteau.

  2. 1. Magnetic bead-based isolation of biological therapeutic modalities

    Author : Nils A. Brechmann; Véronique Chotteau; Nigel Titchener-Hooker; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Magnetic bead separation; Magnetic beads; Protein A; Protein G; Negative cell isolation; Monoclonal antibody; induced pluripotent stem cells; human mesenchymal stem cells; Allogenic cell therapy; Biomanufacturing; cell clarification; Biotechnology; Bioteknologi;

    Abstract : Biopharmaceutical modalities, such as monoclonal antibodies or the less established cell therapies, are nowadays very important for the treatment of severe or incurable diseases. The manufacturing of such modalities is complex and costly, including the downstream processing, which is highly essential to ensure the safety and quality of the product. READ MORE

  4. 2. Macroscopic models of Chinese hamster ovary cell cultures

    Author : Erika Hagrot; Véronique Chotteau; Anders Forsgren; Nathan E. Lewis; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chinese hamster ovary; Amino acid; Metabolic network; Metabolic flux analysis; Kinetic modeling; Elementary flux mode; Optimization; Column generation; Bioteknologi; Biotechnology;

    Abstract : Biopharmaceuticals treat a range of diseases, and is a growing sector within the pharmaceutical industry. A majority of these complex molecules are produced by genetically modified mammalian cells in large-scale cell cultures. READ MORE

  5. 3. Tools for the development of intensified perfusion processes for mammalian cell culture

    Author : Hubert Schwarz; Véronique Chotteau; Mark Smales; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Recombinant protein biomanufacturing; Perfusion process; Integrated continuous bioprocessing; Monoclonal antibody; Erythropoietin; Chinese Hamster Ovary cells; Human Embryonic Kidney cells; Perfusion medium optimization; Cell specific perfusion rate; Raman spectroscopy; N-glycosylation; Microbioreactors; Design of Experiments; Biotechnology; Bioteknologi;

    Abstract : Recombinant protein therapeutics have become an indispensable part of modern medicine to treat a wide variety of diseases. Their manufacture is mostly based on mammalian cells with fed-batch production bioreactors and downstream batch purification unit operations. READ MORE

  6. 4. Hydrodynamics considerations in cells systems from ocean flow to perfusion cultivation process

    Author : Caijuan Zhan; Véronique Chotteau; Jeffrey Chalmers; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Microorganism; cells; hydrodynamics; turbulence; numerical simulation; CFD; Resonance; Wave bioreactor; ATF; TFF; perfusion; design feeding strategy; Bioteknologi; Biotechnology;

    Abstract : Microorganisms and animal cells are grown surrounded by fluid, which is providing them with nutrients and removing their waste products. In nature and industry processes, cells/microbes can be subject to aggressive environments, such as turbulent flow or shear flow. READ MORE

  7. 5. Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

    Author : Liang Zhang; Véronique Chotteau; Michael J. Betenbaugh; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chinese hamster ovary cells; glycosylation; IgG; mathematical modelling; experimental design; perfusion; carbon sources; GReBA; Bayesian network; probabilistic graphic model; Bioteknologi; Biotechnology;

    Abstract : Chinese hamster ovary (CHO) cells are the most popular expression system for the production of biopharmaceuticals. More than 80% of the approved monoclonal antibodies (mAbs) or immunoglobulin G (IgG) are produced with these cells. Glycosylation is a usual post- translational modification important for therapeutic mAbs. READ MORE