Search for dissertations about: "V gene"

Showing result 1 - 5 of 513 swedish dissertations containing the words V gene.

2. 1. Genetic Determinants of Dyslipidemia

   University dissertation from Lund University: Faculty of Medicine

   Author : Tibor V Varga; [2016]
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetic epidemiology; Genetic polymorphism; dyslipidaemia; Cholesterol; Triglyceride; Genetic risk; genetic risk score; Single nucleotide polymorphism; Prediction; Gene-environment interactions; Randomized controlled trial; prospective cohort studies; Observational study; GLACIER Study; Diabetes Prevention Program;

   Abstract : Dyslipidemia is a chronic deviation from normal blood lipid levels that can lead to atherosclerosis and other cardiovascular diseases; dyslipidemia and its sequelae are caused by the complex interplay of genetic and environmental factors. Although circulating concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (LDL-C) have a strong genetic underpinning, not much is known about the genetic factors that affect long-term deteriorations in lipid concentrations. READ MORE

4. 2. Epigenic regulation and posttranslational modification of human cytochrome P450s : Focus on CYP2W1, CYP1A2 and CYP2C18

   University dissertation from Stockholm : Karolinska Institutet, Department of Physiology and Pharmacology

   Author : Alvin V Gomez; Karolinska Institutet.; Karolinska Institutet.; [2008]
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : The cytochrome P450 superfamily represents a very important group of enzymes that are responsible for the metabolism of drugs as well as of endogenous compounds. Many P450s are genetically polymorphic causing important interindividual variability in P450 expression and activity whereas in some cases the basis for interindividual variation has still not been resolved. READ MORE

5. 3. Mechanisms of intestinal tumor initiation and progression in ApcMin mouse model of colorectal cancer

   University dissertation from Stockholm : Karolinska Institutet, Department of Physiology and Pharmacology

   Author : Zhiyuan V. Zou; Göteborgs universitet.; Gothenburg University.; [2018]
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; ApcMin mouse;

   Abstract : Colorectal cancer (CRC) is a cancer that occurs in the colon or rectum and is one of the most common cancer forms and a leading cause of cancer death in the Western world. The majority of CRCs are caused by inherited or somatic mutations in the APC gene. READ MORE

6. 4. Characterization and Evolution of Transmembrane Proteins with Focus on G-protein coupled receptors in Pre-vertebrate Species

   University dissertation from Uppsala : Acta Universitatis Upsaliensis

   Author : Karl J. V. Nordström; Helgi B. Schiöth; Robert Fredriksson; Teresa Attwood; [2010]
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G protein-coupled receptors; GPCR; Membrane protein; Rhodopsin; Adhesion; Secretin; Evolution; Bioinformatics; Phylogeny; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning; NATURAL SCIENCES Biology Other biology Bioinformatics; NATURVETENSKAP Biologi Övrig biologi Bioinformatik; Bioinformatik; Bioinformatics; Biology with specialization in Molecular Evolution; Biologi med inriktning mot molekylär evolution;

   Abstract : G protein-coupled receptors (GPCRs) are one of the largest protein families in mammals. GPCRs are instrumental for hormonal and neurotransmitter signalling and are important in all major physiological systems of the body. READ MORE

7. 5. The MUC2 mucin -A network in the intestinal protective mucus

   University dissertation from Uppsala : Acta Universitatis Upsaliensis

   Author : Malin E V Johansson; Göteborgs universitet.; Gothenburg University.; [2009]
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucus; Muc2; trimer; proteomics; intestine; colitis; DSS;

   Abstract : The intestine is covered by mucus that is the first line of defence of the epithelium. The main structural component of the intestinal mucus is the MUC2 mucin. This is a large glycoprotein with two long and heavily O-glycosylated mucin domains. READ MORE