Search for dissertations about: "VLCFA"

Found 3 swedish dissertations containing the word VLCFA.

  2. 1. Elovl3 and very long chain fatty acids; role in metabolism

    Author : Andreas Jakobsson; Anders Jacobsson; James Ntambi; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fatty acids metabolism elongation; Physiology; Fysiologi;

    Abstract : Fatty acids (FA) are important in several aspects of cellular function, for example as structural molecules and metabolic substrates. The bulk of FA up to 16 carbons (palmitic acid) in length are synthesised by a cytosolic enzyme complex called fatty acid synthase (FAS), while FA can be further elongated into very long-chain fatty acids (VLCFA) by membrane-bound enzymes in the endoplasmatic reticulum (ER). READ MORE

  4. 2. Regulation of Elovl and fatty acid metabolism

    Author : Annelie Brolinson; Anders Jacobsson; Jaap Keijer; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fatty acid metabolism; fatty acid elongation; Physiology; Fysiologi; Physiology; fysiologi;

    Abstract : Fatty acids are important regulators in the control of mammalian energy homeostasis. They are ingested in the diet but a significant amount are also endogenously produced by de novo lipogenesis. READ MORE

  5. 3. A molecular chaperone that governs membrane contact sites and lipid metabolism

    Author : Sergi Tosal Castaño; Sabrina Büttner; W. Mike Henne; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yeast; nucleus-vacuole junctions; proteostasis; unfolded protein response; fatty acid elongation; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Transmembrane proteins represent almost one third of the total cellular proteome, and the majority of them requires translocation into the endoplasmic reticulum (ER) to be folded, sorted and transported to their final subcellular destination. High translational rates during exponential cell growth result in a massive influx of immature proteins into the ER, requiring rapid and accurate folding. READ MORE