Search for dissertations about: "VP22"

Found 2 swedish dissertations containing the word VP22.

  1. 1. Vector development for suicide gene therapy

    Author : Alar Aints; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Suicide gene therapy; VP22; selection markers; Ouabain resistance gene; GvHD; retroviral gene transfer;

    Abstract : Gene therapy is used to treat conditions that arise from errors in the genetic makeup of cells either congenital diseases resulting from a deletion or mutation in a gene or malignant diseases where genetic regulation mechanisms have been deranged. Suicide gene therapy is one of several gene therapeutic approaches to treat cancer. READ MORE

  2. 2. Cloning and characterization of human glutaredoxins

    Author : Mathias Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Reactive oxygen species, ROS, are generated in cells during aerobic metabolism. High and sustained levels of ROS pose a serious threat to all major cellular components, DNA, proteins mid lipids whereas controlled and physiological concentrations play a central role as a second messenger signal molecule involved in cell functions including, differentiation, proliferation, and apoptosis. READ MORE