Search for dissertations about: "VTA"

Showing result 1 - 5 of 37 swedish dissertations containing the word VTA.

  2. 1. Across Borders : A Histological and Physiological Study of the Subthalamic Nucleus in Reward and Movement

    Author : Nadine Schweizer; Åsa Wallén-Mackenzie; Dai Stephens; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subthalamic nucleus; STN; basal ganglia; locomotion; hyperlocomotion; rearing; ventral tegmental area; VTA; dopamine; glutamate; vesicular glutamate transporter 2; Vglut2; Parkinson s disease; deep brain stimulation; subpopulation; conditional knock-out; optogenetic; co-expression; in situ hybridization; self-administration; reward behavior; mouse genetics;

    Abstract : The basal ganglia are the key circuitry controlling movement and reward behavior. Both locomotion and reward-related behavior are also modified by dopaminergic input from the substantia nigra and the ventral tegmental area (VTA). READ MORE

  4. 2. Importance of endogenous kynurenic acid in brainm catecholaminergic processes and in the pathophysiology of schizophrenia

    Author : Sophie Erhardt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Schizophrenia; kynurenic acid; nicotine; VTA; dopamine; NMDA-receptors;

    Abstract : Kynurenic acid is a metabolite of tryptophan and the only known naturally occurring NMethylD-Aspartic acid (NMDA)-receptor antagonist (at the co-agonist glycine site) in the human brain. The aim of the present work was to investigate the physiological and pharmacological significance of endogenous kynurenic acid as well as its putative pathophysiological implications. READ MORE

  5. 3. On natural and drug-induced reward : genetic, biochemical and behavioral comparisons

    Author : Martin Werme; Karolinska Institutet; Karolinska Institutet; []
    Keywords : VTA; nucleus accumbens; wheel running; exercise; drugs of abuse; addiction; compulsive; deltaFosB; Nurr1; Dynorphin;

    Abstract : Work in this thesis compares natural and drug- induced reward at genetic, biochemical and behavioral levels with the objective to obtain information about key mechanisms underlying reward and addiction, and improve the understanding of compulsive elements that characterize addiction. Surveys among committed human runners have described running as addictive. READ MORE

  6. 4. Exploring Diversity in the Midbrain Dopamine System with Emphasis on the Ventral Tegmental Area

    Author : Bianca Vlcek; Åsa Mackenzie; Eva Hedlund; Uppsala universitet; []
    Keywords : ;

    Abstract : Midbrain dopamine neurons of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) are important for motor, cognitive and limbic functions through substantial projections to forebrain structures. Dysfunction of the midbrain dopamine system is associated with several disorders, including Parkinson´s disease (PD) and substance use disorder. READ MORE

  7. 5. Substance P Endopeptidase : Purification and Characterizataion of Enzyme Activity and Evaluation of its Function during Stressful Condition

    Author : Krister Karlsson; Lars Oreland; Fred Nyberg; Tsukasa Sakurada; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Substance P Endopeptidase; Neuropeptide; Central Nervous System; Purification; Drug Dependence; Heat Stress; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Abstract : The purification and biochemical characterization of the substance P (SP) hydrolyzing enzyme, substance P endopeptidase (SPE), have been carried out; with subsequent orientation in neurobiological fundamental processes involved in opioid dependence, withdrawal, and heat-stress.SPE was purified from rat spinal cord, human spinal cord and cerebrospinal fluid (CSF), rat ventral tegemental area (VTA), and rat hippocampus. READ MORE