Search for dissertations about: "VWF"
Showing result 1 - 5 of 39 swedish dissertations containing the word VWF.
-
1. The hemostatic pathway in ischemic stroke. Clinical studies of genetic variation and plasma protein measurements
Abstract : Although stroke is a common cause of death and disability in adults, there are few studies on stroke compared to other common diseases. A stroke could be either ischemic or hemorrhagic, but even within these two groups, disease etiology shows heterogeneity. READ MORE
-
2. Adipocyte-derived hormones and cardiovascular disease
Abstract : Obesity is increasing globally and related to major changes in lifestyle. This increase is associated with an increased risk of cardiovascular disease (CVD). Knowledge about adipose tissue as a metabolic-endocrine organ has increased during the last few decades. READ MORE
-
3. ADAMTS13 phenotype in health and disease with special reference to thrombotic thrombocytopenic purpura
Abstract : Von Willebrand factor (VWF) is synthesized and secreted by endothelial cells into the plasma as a series of multimers. VWF induces the formation of platelet plugs at sites of vascular injury and high shear stress. Biological activity is dependent on multimeric size, which is regulated in plasma by the VWF-cleaving protease ADAMTS13. READ MORE
-
4. Genetic characterization of families with von Willebrand disease
Abstract : von Willebrand disease (VWD) is the most common hereditary bleeding disorder. It is caused by quantitative and/or qualitative defects of the von Willebrand factor (VWF). The severity of the disease can vary considerably, as can the hereditary patterns. READ MORE
-
5. Studies of the pathogenesis of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura
Abstract : This study investigated the pathogenesis of hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). (1) The relative roles of lipopolysaccharide and Shiga-like toxin-2 were studied in a mouse model of Escherichia coli O157:H7 infection. READ MORE