Search for dissertations about: "VagH"

Found 2 swedish dissertations containing the word VagH.

2. 1. Meticulous control of the T3SS of Yersinia is essential for full virulence

   Author : Ann-Catrin Björnfot; Hans Wolf-Watz; Kelly T. Hughes; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia; type III secretion; YscU; substrate specificity switch; heat shock proteins; VagH; methyltransferase; virulence; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Abstract : The type III secretion system (T3SS) of pathogenic Yersinia pseudotuberculosis is involved in virulence. The syringe-like secretion system spans both bacterial membranes and is responsible for the ability of Yersinia to transfer toxic proteins (Yop proteins) into the eukaryotic target cell. READ MORE

4. 2. A strategy to identify novel antimicrobial compounds : a bioinformatics and HTS approach

   Author : Sara Garbom; Hans Wolf-Watz; Dan Andersson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; Yersinia; T3SS; virulence associated genes; VagH; HemK PrmC; Release factors; small molecular inhibitors; HTS; Medical microbiology; Medicinsk mikrobiologi;

   Abstract : Bacterial infections are again becoming difficult to treat because the microbes are growing increasingly resistant to the antibiotics in use today. The need for novel antimicrobial compounds is urgent and to achieve this new targets are crucial. In this thesis we present a strategy for identification of such targets via a bioinformatics approach. READ MORE