Search for dissertations about: "Vaia Stavropoulou"

Found 1 swedish dissertation containing the words Vaia Stavropoulou.

2. 1. Role of Tripeptidyl peptidase II in cell cycle regulation and tumor progression

   Author : Vaia Stavropoulou; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Apoptosis; Burkitt s lymphoma; cell cycle; centrosome; genetic instability; Golgi; mitosis; tripeptidyl-peptidase II;

   Abstract : Protein degradation is essential for many cellular functions and the ubiquitin-proteasome system controls the turnover of most cellular proteins and plays a pivotal role in the regulation of basic physiological processes and in the pathogenesis of many diseases. Alterations in the metabolism of proteins involved in the regulation of cell cycle and apoptosis may result in uncontrolled cell division, which em lead to malignant transformation and tumor development One melt example is the Burkitt's lymphoma (BL), a highly malignant B-cell tumor characterized by chromosomal translocations that constitutively activate the c-myc oncogene. READ MORE