Search for dissertations about: "Vascular: drug effects"

Showing result 11 - 15 of 54 swedish dissertations containing the words Vascular: drug effects.

  2. 11. Endothelial and cardiac effects of 5-fluorouracil. An experimental and clinical study

    Author : Sara Kinhult; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Cytology; endothelin; onkologi; Cytologi; cancer; von Willebrand factor; thrombomodulin; lipoperoxidation; probucol; low-molecular weight heparin; scanning electron microscopy; 5-fluorouracil; endothelium;

    Abstract : The cytostatic drug 5-fluorouracil (5-FU) has been shown to affect both morphology and function of vascular endothelium. These effects could be part of the pathophysiology for 5-FU induced cardiotoxicity. The present thesis explores the mechanisms of this endothelial toxicity. READ MORE

  4. 12. Pleiotropic effects of HMG-CoA reductase inhibitors : studies in vitro and in vivo

    Author : Cristine Skogastierna; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cardiovascular disease (CVD) is the prime cause of death in industrialized countries, resulting from the progression of atherosclerotic lesions. An increased level of plasma cholesterol, particularly within low-density lipoproteins, is a principle risk factor, but also elevated triglycerides and low levels of high-density lipoprotein cholesterol. READ MORE

  5. 13. Non-coding RNA-based therapeutics and biomarkers for treatment and detection of vascular disease

    Author : Greg Winski; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cardiovascular disease (CVD), with atherosclerosis as its main underlying pathology, is the most prominent cause of death worldwide. Progression and rupture of atherosclerotic plaques lead to potential adverse pathological events such as myocardial infarction and stroke. READ MORE

  6. 14. Ropivacaine : An experimental and clinical study with special reference to analgesic, circulatory and antiinflammatory effects

    Author : Ingemar Cederholm; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Aims of the study: 1. to compare ropivacaine, a new long-acting amino-amide local anaesthetic drug, and bupivacaine (with/without adrenaline) concerning dermal analgesia and local vascular effects, 2. to design a suitable test procedure to evaluate changes in skin blood flow after intradermal injection of local anaesthetics, 3. READ MORE

  7. 15. Alcohol and inflammation : a study of effects of ethanol on endothelial and epithelial cell functions

    Author : Anne-Sofie Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Although short–term alcohol drinking causes euphoric and stress relieving effects, alcohol abuse is a major risk factor for neurobehavioural, liver and muscle injury as well as reduced host defence with enhanced susceptibility to bacterial infections. Although such reductions also suggest potential use as an anti-inflammatory drug, well known side effects of ethanol limits its clinical use. READ MORE