Search for dissertations about: "Vascular: drug effects"

Showing result 16 - 20 of 54 swedish dissertations containing the words Vascular: drug effects.

  2. 16. Vascular and endothelial function in human hypertension, and the importance of the renin-angiotensin-aldosterone system

    Author : Andreas Jekell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Hypertension induces structural vascular and cardiac changes with increased arterial stiffness and left ventricular (LV) hypertrophy and is major risk factor for cardiovascular morbidity and mortality. The renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system are important for blood pressure regulation and vascular function. READ MORE

  4. 17. Extracellular matrix-mediated signaling in the regulation of vascular smooth muscle cell phenotype and function

    Author : Joy Roy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cardiovascular disease is the leading cause of mortality in the world. Even though death rates are today dropping in the developed countries, disability due to the disease is rising worldwide. The major portion of cardiovascular disease associated deaths is due to occlusive atherosclerotic lesions. READ MORE

  5. 18. Hemorphins and endomorphins

    Author : Katarina Sanderson Nydahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Hemorphins; endomorphins; opioid receptors; peptide metabolism; neurogenic inflammation; pain; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; biologisk beroendeforskning; Biological Research on Drug Dependence;

    Abstract : In this thesis, two newly discovered endogenous opioid peptide families, the hemorphins and endomorphins, are investigated with emphasis on modulation of pain and inflammation. In addition, the presence of hemorphins in human biological fluids as well as the in vitro and in vivo processing ofLVV-hemorphin-7 in blood and brain is investigated. READ MORE

  6. 19. Blood pressure, blood pressure variability and myocardial ischemia : studies in patients with peripheral arterial disease and matched control subjects

    Author : Per Svensson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Peripheral vascular diseases; hypertension drug therapy; ambulatory blood pressure monitoring; coronary artery disease; ambulatory electrocardiography; SPECT; NT-proBNP;

    Abstract : Background: Patients presenting with peripheral arterial disease (PAD) often have concomitant coronary artery disease (CAD), which is frequently asymptomatic. Ambulatory blood pressure (ABP) monitoring improves risk stratification in hypertensive patients beyond that offered by office BP(OBP) measurements. READ MORE

  7. 20. Assessment of microvascular function by use of transdermal iontophoresis : methodological aspects

    Author : Erik Droog Tesselaar; Folke Sjöberg; Angela Shore; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Iontophoresis; Microcirculation; Laser-Doppler; Acetylcholine; Sodium nitroprusside; Pharmacodynamics; Pharmacokinetics skin; Physiology and pharmacology; Fysiologi och farmakologi;

    Abstract : Assessment of the microcirculation is of major importance in understanding the physiology of the vasculature and in assessing te vascular effects of pathological conditions such as diabetes, hypertension and sepsis. Transdermal iontophoresis can be used to non‐invasively introduce vasoactive drugs into the skin. READ MORE