Search for dissertations about: "Vascular laminin isoforms"

Showing result 1 - 5 of 7 swedish dissertations containing the words Vascular laminin isoforms.

  2. 1. Interaction of human blood platelets, lymphocytes and monocytes with vascular laminin isoforms

    Author : Gezahegn Gorfu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Vascular laminin isoforms; extracellular matrix; integrins; cell adhesion; cell migration; high endothelial venules; lymphocytes; monocytes; platelets; leukocyte extravasation;

    Abstract : Inflammatory and immune responses play a fundamental role in both health and disease, and leukocytes are important actors in these processes. Migration of the leukocytes to sites of injury or inflammation is a crucial component of innate and adaptive immunity. It is currently accepted that leukocyte extravasation is a multistep process. READ MORE

  4. 2. Laminins in blood vessel development and disease -functional aspects in angiogenesis, atherosclerosis, and muscular dystrophy

    Author : Alexander Nyström; Muskelbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vasculature; angiogenesis; Medicine human and vertebrates ; disease; LG domains; Laminin; Medicin människa och djur ;

    Abstract : Basement membranes are sheet like extracellular matrices that underlie or surround many cell types. They are crucial for key cellular events such as cell migration, proliferation, survival and differentiation. Vital components of all basement membranes are laminins, heterotrimeric combinations of different laminin chain isoforms. READ MORE

  5. 3. Extracellular matrix in atherosclerotic plaques: its role in plaque stability

    Author : Christoffer Tengryd; Kardiovaskulär forskning - translationella studier; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Extracellular matrix; Laminin; Collagen; Proteoglycans; Atherosclerosis; Carotid plaque; TGF-β;

    Abstract : Atherosclerosis is a systemic disease affecting the large arteries caused by the accumulation of lipids in the vessel wall. Cardiovascular disease due to atherosclerosis is today the most common cause of death globally through its end consequences: myocardial infarctions and stroke. READ MORE

  6. 4. The diverse role of laminin isoforms in neuronal cells, human mast cells and blood platelets

    Author : Wondossen Sime; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Laminins; extracellular matrix; integrins; tooth pulp fibroblasts; mast cells; megakaryocytes; platelets; cell adhesion; cell migration; neurite outgrowth;

    Abstract : The close interaction of cells with other cells and with extracellular matrix (ECM) components is a prerequisite in a number of biological activities. During development of the nervous system, axons often navigate a considerable distance depending on the type of molecular factors they encounter. READ MORE

  7. 5. Primary structure, expression and function of laminin [alpha]4

    Author : Jarkko Kortesmaa; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Basement membranes (BMs) are thin extracellular sheet-like structures that compartmentalize tissues. They are found beneath epithelia and endothelia, and surrounding individual cells, such as muscle fibers, neurons and adipocytes. Laminins, type IV collagens, perlecan and nidogens are some of the main components of mature basement membranes. READ MORE