Search for dissertations about: "Vascular smooth muscle cells"

Showing result 11 - 15 of 162 swedish dissertations containing the words Vascular smooth muscle cells.

2. 11. Inducible nitric oxide synthase : in vascular smooth muscle cells

   Author : Zhong-qun Yan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : nitric oxide; nitric oxide synthase; vascular smooth muscle cells; transcriptional regulation; NF-[kappa]B; I[kappa]B; pathophysiological role;

   Abstract : Besides the constitutively expressed nitric oxide synthase (NOS) in endothelial cells, vascular smooth muscle cells (SMC) have the potential to express the inducible isoform of NOS (iNOS). Given the important effects of nitric oxide and the high output of this enzyme, expression of iNOS in SMC and its pathophysiological significance were investigated in the present study. READ MORE

4. 12. Mechanisms of stretch-induced growth and contractile differentiation in vascular smooth muscle

   Author : Asad Zeidan; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fysiologi; Physiology; SM22a; ERK1 2; caveolae; stretch; Smooth muscle; differentiation;

   Abstract : Vascular smooth muscle can adapt to increased intraluminal pressure by remodelling and hypertrophy, as seen in hypertension. The molecular mechanisms responsible for this are still incompletely characterized. READ MORE

5. 13. Cyclic nucleotide signalling systems in vascular smooth muscle cells and immune system cells with special reference to phosphodiesterases PDE3 and PDE4

   Author : Dag Ekholm; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HTLV-I; multiple sclerosis; proliferation; phosphorylation; T-lymphocytes; vascular smooth muscle; cloning; protein kinase A; cGMP; cAMP; PDE4; Phosphodiesterase; PDE3; cilostamide; rolipram; Histology; cytochemistry; histochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur;

   Abstract : The cyclic nucleotide signalling systems are important in vascular smooth muscle and in the immune system, and are of interest from a pharmacological point of view. Drugs which interfere with the cyclic nucleotide levels have profound effects on heart, blood vessels and airways and have actual or potential use in several important diseases, such as heart failure, hypertension, arteriosclerosis, asthma and autoimmune diseases. READ MORE

6. 14. Tissue engineering in blood vessels

   Author : Gisela Helenius; Göteborgs universitet; []
   Keywords : tissue engineering; vascular graft; endothelial cells; smooth muscle cells; thrombogenicity; mechanical properties; scaffold; bacterial cellulose;

   Abstract : Severely occluded coronary- and peripheral arteries, caused by atherosclerotic plaques, are treated with bypass surgery. Autologous veins are the most commonly used replacement graft. Among the patients that need a vascular bypass, 5-10% lack appropriate replacement veins due to previous surgery of bad quality of the vessels. READ MORE

7. 15. Vascular actions of antimicrobial peptides

   Author : Cristina Ciornei; Sektion II; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; vascular smooth muscle; sepsis; nitric oxide; human antimicrobial peptide LL-37; Antimicrobial peptides; lipopolysaccharide; bactericidal permeability-increasing protein;

   Abstract : The present thesis focuses on the vascular effects of antimicrobial peptides especially mechanisms involving the vasodilator nitric oxide (NO), which is released from the blood vessel wall during inflammatory conditions such as sepsis. Bacterial lipopolysaccharide stimulates the expression of nitric oxide synthase (iNOS), which increases the NO production in vascular tissues or cultured vascular smooth muscle cells (VSMC). READ MORE