Search for dissertations about: "Vendela Asp"

Found 1 swedish dissertation containing the words Vendela Asp.

  1. 1. In Vitro Studies of Adrenocorticolytic DDT Metabolites, with Special Focus on 3-methylsulfonyl-DDE

    University dissertation from Uppsala, Sweden : Acta Universitatis Upsaliensis

    Author : Vendela Asp; Ingvar Brandt; Ulrika Bergström; Olle Söder; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicity; 3-methylsulfonyl-DDE; CYP; adrenal cortex; metabolic activation; steroid hormones; Y-1; H295R; mitotane; adrenocortical carcinoma; NATURAL SCIENCES Biology Cell and molecular biology Toxicology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Toxikologi; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Abstract : The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO2-DDE) is bioactivated by cytochrome P450 11B1 (CYP11B1) in the adrenal cortex of mice and forms irreversibly bound protein adducts, reduces glucocorticoid secretion, and induces cell death selectively in cortisol-producing adrenocortical cells. 3-MeSO2-DDE has therefore been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) therapy. READ MORE