Search for dissertations about: "Viperin"

Showing result 1 - 5 of 6 swedish dissertations containing the word Viperin.

  2. 1. Viperin vs. tick-borne encephalitis virus : mechanism of a potent antiviral protein

    Author : Kirstin Vonderstein; Anna Överby Wernstedt; Magnus Evander; Sonja Best; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; TBEV; type-I interferon; IFN; Interferon-stimulated gene; ISG; viperin; GBF1; CIAO1; antiviral protein; genome replication; particle release; capsid;

    Abstract : Tick-borne encephalitis virus (TBEV) is a very important virus medically, causing mild or severe encephalitis often with long-lasting sequelae. Treatment of tick-borne encephalitis is limited to supportive care, and antiviral drugs are much needed.The type-I interferon (IFN) system is the first line of host defense against many viruses. READ MORE

  4. 2. The role of the type I interferons and viperin during neurotropic flavivirus infection

    Author : Richard Lindqvist; Anna Överby Wernstedt; Daniel Ruzek; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TBEV; Flavivirus; Interferon; Neurotropic; Viperin;

    Abstract : Flaviviruses are globally distributed pathogens that cause millions of human infections annually. One of the most detrimental outcomes of flavivirus infection is encephalitis, which is caused by neurotropic flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), and Tick-borne encephalitis virus (TBEV). READ MORE

  5. 3. Interplay between tick-borne encephalitis virus and the host innate immunity

    Author : Chaitanya Kurhade; Anna Överby Wernstedt; Nelson Gekara; Helen Lazear; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Flavivirus; IPS-1; Interferon; Viperin; mikrobiologi; Microbiology;

    Abstract : Flaviviruses are important emerging and re-emerging arthropod-borne pathogens that cause significant morbidity and mortality in humans. It consists of globally distributed human pathogens such as tick-borne encephalitis virus (TBEV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), dengue virus (DENV), and Zika virus (ZIKV). READ MORE

  6. 4. Viperin, a multifunctional radical SAM enzyme : biogenesis and antiviral mechanisms

    Author : Arunkumar Upadhyay; Anna K. Överby; Niklas Arnberg; Richard Lundmark; Michael Beard; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Viperin (virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is an interferon-induced antiviral protein. It has three distinct functional domains: the N-terminal domain, the radical SAM (S-adenosylmethionine) domain for binding iron-sulphur cluster, and the C-terminus domain. READ MORE

  7. 5. Inflammation in atherosclerosis

    Author : Ken Jatta; Allan Sirsjö; Michael D. Menger; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; chemokine; cytokine; inflammation; Lipopolysacchride; Carotid lesion; interleukin; viperin Cig5; smooth muscle cells; Cardiovascular medicine; Kardiovaskulär medicin; MEDICINE; MEDICIN; Biomedicin; Biomedicine;

    Abstract : Consequences of atherosclerosis may result in a number of diseases of the cardiovascular system that represent serious health problems and major causes of morbidity and mortality worldwide. Although it is initially considered as disease of fibro-lipid and thrombus deposition in the arterial wall, it also involves an ongoing inflammatory response. READ MORE