Search for dissertations about: "WAY 100635"

Showing result 1 - 5 of 11 swedish dissertations containing the words WAY 100635.

2. 1. Photoinitiated Radical Carbonylation Using [11C]Carbon Monoxide : 11C-Labelling of Aliphatic Carboxylic Acids, Esters, and Amides

   Author : Oleksiy Itsenko; Bengt Långström; Tor Kihlberg; Chryssostomos Chatgilialoglu; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; 11C-labelling; radicals; carbonylation; carbon monoxide; solvent effects; sensitizers; sulfoxides; WAY-100635; PET; Organisk kemi; Organic chemistry; Organisk kemi;

   Abstract : One-step photoinitiated free radical carbonylation was employed for the rapid (5–7 min) labelling of aliphatic carboxylic acids, esters, and amides with a short-lived positron emitter 11C (t½ = 20.3 min) at the carbonyl position. The labelled compounds were synthesized from alkyl iodides (0.05–0. READ MORE

4. 2. Experimental studies on novel pharmacological strategies in the treatment of schizophrenia

   Author : Amani Eltayb; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Schizophrenia; L-dopa; topiramate; 5-HT2C; citalopram; WAY 100635; CAR; catalepsy;

   Abstract : The modified dopamine (DA) hypothesis of schizophrenia suggests a hyperdopaminergic state in subcortical brain regions, which is believed to cause positive symptoms, while cortical regions may show a hypodopaminergic state which is believed to generate negative and cognitive symptoms. Positive symptoms are improved by typical antipsychotic drug (APD) treatment. READ MORE

5. 3. PET studies of the serotonin transporter in the human brain

   Author : Johan Lundberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : positron emission tomography; MADAM; WAY 100635; 5-HTT; 5-HT1A receptors; receptor occupancy; major depressive disorder; citalopram; escitalopram;

   Abstract : The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination of neurotransmission systems in the human brain in vivo. READ MORE

6. 4. Positron emission tomography in serotonergic drug development

   Author : Bengt Andrée; Karolinska Institutet; Karolinska Institutet; []
   Keywords : PET; 5-HT1A receptors; 5-HT2A receptors; D2 dopamine receptors; antidepressive drugs; antipsychotic drugs; pindolol; NAD-299; S 16924; ORG 5222; M100907; WAY; DWAY;

   Abstract : The serotonin neurotransmission system has a central role in drug treatment of depression and anxiety and is also discussed in relation to treatment of schizophrenia. The benefits of presently available drugs are however limited by partial of poor response and side effects. READ MORE

7. 5. Development of positron emission tomography radioligands for the dopaminergic and serotonergic neurotransmission systems

   Author : Camilla Lundkvist; Karolinska Institutet; Karolinska Institutet; []
   Keywords : PET; Radioligand; Dopamine transporter; Serotonin transporter; 5-HT1A receptor; 5-HT2A receptor;

   Abstract : The dopaminergic and serotonergic neurotransmission systems are of central interest in relation to several neuropsychiatric disorders. The main objectives were to develop new suitable radioligands for positron emission tomography (PET) examinations of the dopamine transporter (DAT) as well as the serotonin 5-HT1A and 5-HT2A-receptors. READ MORE