Search for dissertations about: "Whole Genome Sequencing"

Showing result 1 - 5 of 202 swedish dissertations containing the words Whole Genome Sequencing.

2. 1. Whole Genome Sequencing of Enterotoxigenic Escherichia coli

   Author : Astrid von Mentzer; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ETEC; whole genome sequencing; evolution; colonization factor; reverse genetics;

   Abstract : Enterotoxigenic Escherichia coli (ETEC) infections are a common cause of diarrhea but little is known about the evolution and genomic composition of ETEC. The main aim of this thesis was to generate a large collection of whole genome sequenced ETEC isolates to study the evolution of such bacteria on a global level and to search for novel colonization factors (CFs) using both classical and cutting-edge genomic techniques. READ MORE

4. 2. Technologies for Single Cell Genome Analysis

   Author : Erik Borgström; Afshin Ahmadian; Sten Linnarsson; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA; sequencing; single molecule; single cell; whole genome amplification; exome sequencing; emulsions; barcoding; phasin; Biotechnology; Bioteknologi;

   Abstract : During the last decade high throughput DNA sequencing of single cells has evolved from an idea to one of the most high profile fields of research. Much of this development has been possible due to the dramatic reduction in costs for massively parallel sequencing. READ MORE

5. 3. Characterizing the spectrum of somatic alterations in canine and human cancers

   Author : Sharadha Sakthikumar; Kerstin Lindblad-Toh; Richard Rosenquist Brandell; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dog; osteosarcoma; hemangiosarcoma; glioblastoma; non-coding; whole-exome; whole-genome; sequencing; bioinformatics; comparative genetics.;

   Abstract : Cancers arise as a result of deleterious somatic alterations accumulating in the genome during the process of cell division. These alterations arise either via exposure to mutagens or due to errors occurring during DNA replication. READ MORE

6. 4. Function and Evolution of Small Regulatory RNAs and their Associated Proteins : A Journey from Genome to Proteome

   Author : Bart Edelbroek; Fredrik Söderbom; Jonathan R. Chubb; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microRNAs; non-coding RNAs; Evolution; Whole Genome Sequencing; Transcriptomics; Proteomics; small RNAseq; Amoebozoa; Multicellular development; Social amoebae; Comparative genomics; Genome annotation; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Abstract : Organisms throughout the tree of life have evolved distinct ways to regulate gene expression. Some of these processes involve non-coding RNAs (ncRNAs), which are not translated but functional nonetheless. These ncRNAs are of utmost importance, with dysregulation of some causing severe developmental effects or even being lethal. READ MORE

7. 5. Phasing single DNA molecules with barcode linked sequencing

   Author : David Redin; Afshin Ahmadian; Ulf Gyllensten; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Single molecule sequencing; DNA barcoding; whole genome haplotyping; linked-read sequencing; phasing; de novo genome assembly.; Biotechnology; Bioteknologi;

   Abstract : Elucidation of our genetic constituents has in the past decade predominately taken the form of short-read DNA sequencing. Revolutionary technology developments have enabled vast amounts of biological information to be obtained, but from a medical standpoint it has yet to live up to the promise of associating individual genotypes to phenotypic states of wide-spread clinical relevance. READ MORE