Search for dissertations about: "Whole-cell currents"

Showing result 1 - 5 of 17 swedish dissertations containing the words Whole-cell currents.

  2. 1. Calcium signaling in astroglial cells. Noradrenergic effects and regulation

    Author : Håkan Muyderman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Astrocytes; Neurons; Noradrenaline; Glutamate; Fluorometry; Fura-2; Fluo-3; PBFI; Digital imaging; Voltage-patch-clamp; Whole-cell currents; Calcium; Potassium; Intercellular communication; Glutamate release; Neuron-glial interactions.;

    Abstract : Astroglial cells are the most common cell type in the central nervous system and express a wide array of ion channels and neurotransmitter receptors. The cells organize into multicellular networks and exhibit a calcium-based excitability in which receptor-mediated calcium elevations propagate as intercellular waves over considerable distances. READ MORE

  4. 2. Histochemical, biochemical and electrophysiological studies on dorsal root ganglion cultures : focusing on galanin, neuropeptide Y and glutamate

    Author : Nora Kerekes; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acute and long-term DRG cultures; aFGF; BDNF; bFGF; bradykinin; excitability; galanin; glutamate; leukemia inhibitory factor; neuropeptide Y; : NGF; regeneration; whole cell patch clamp.;

    Abstract : Galanin (Gal) and neuropeptide Y (NPY) are two peptides, which are strongly up- regulated in a population of dorsal root ganglion (DRG) neurons after peripheral nerve injury (axotomy). Both peptides may be involved in the control of pain sensation, especially after nerve injury (neuropathic pain). READ MORE

  5. 3. GABA signaling regulation by GLP-1 receptor agonists and GABA-A receptors modulator

    Author : Omar M. Babateen; Bryndis Birnir; Lena Eliasson; Uppsala universitet; []
    Keywords : Neuroscience; Neurovetenskap;

    Abstract : GABA (γ-aminobutyric acid) is the main neuroinhibitory transmitter in mammalian brains.  It binds to GABA-A and GABA-B receptors. The GABA-A receptors are ligand-gated chloride channels. A variety of GABA-A receptor agonists and antagonists have been developed to study the GABA-mediated inhibition and to explore new medications. READ MORE

  6. 4. Mechanism of Action of the Antiarrhythmic Agent AZD7009

    Author : Frida Persson; Göteborgs universitet; []
    Keywords : atrial fibrillation; antiarrhythmic drug; IKr; IKur; Ito; IKs; IKACh; INa; ICaL; cardiac action potential; early afterdepolarisation;

    Abstract : Atrial fibrillation (AF) is the most common tachyarrhythmia in the adult population and is a major cause of morbidity and mortality. AF can be terminated and sinus rhythm restored by prolonging the action potential duration (APD) and the refractory period. READ MORE

  7. 5. Plasticity and variation of synaptic responses in hippocampus. Role of AMPA and NMDA receptors

    Author : Yin-Ping Niu; Göteborgs universitet; []
    Keywords : learning and memory; synaptic plasticity; hippocampus; synapse; AMPA receptor; NMDA receptor; LTP; LTD; CV; TFS;

    Abstract : It is generally believed that synaptic plasticity in the central nervous system may underlie learning and memory as well as neuronal development. The most wellstudied examples of such synaptic plasticity are long-term potentiation (LTP) andlong-term depression (LTD). READ MORE