Search for dissertations about: "Wilms tumour WT1"
Found 5 swedish dissertations containing the words Wilms tumour WT1.
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1. WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?
Abstract : Wilms’ tumour gene 1 (WT1) encodes a zinc-finger transcription factor functioning as a key regulator in organ development. WT1 was first identified as a tumour suppressor gene due to its inactivation in Wilms’ tumour cases, a childhood kidney cancer. READ MORE
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2. Structural and Functional Studies of the Wilms' Tumour 1 Protein (WT1) in Interaction with Nucleic acids
Abstract : The WT1 protein, a product of the Wilms’ tumour 1 gene (WT1) is a zinc finger transcription factor implicated in a number of cellular processes particularly involved in the development of the urogenital system. Mutations in this gene have been implicated in abnormal development of the urogenital system resulting in syndromes such as the Denys-Drash, WAGR and Frasier and in the childhood kidney malignancy, Wilms’ tumour. READ MORE
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3. Structural and Functional Studies of Wilms Tumour Protein - WT1; Novel Insights into Functionality of Zinc Finger Proteins
Abstract : The molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. READ MORE
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4. Mass Spectrometry-Based Protein Biomarker Discovery in Pancreatic Cancer
Abstract : Background: Pancreatic cancer has the lowest survival rate among all the major cancer types. Although recent decades have seen advances in diagnostic imaging, surgical techniques, perioperative care and oncological treatment, this has not been translated into major improvements in clinical outcome. READ MORE
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5. How can p53 induce differentiation of leukemic cells?
Abstract : The terminal differentiation of leukemic cells is closely connected to their death. The concept of differentiation therapy originates from the idea that forced maturation of leukemic cells could induce cell death without the side-effects that are provoked by ordinary chemotherapy. READ MORE