Search for dissertations about: "Wnt pathway"

Showing result 1 - 5 of 87 swedish dissertations containing the words Wnt pathway.

  2. 1. Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing

    Author : Anna Thorfve; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wnt signaling pathway; Osteoarthritis; Bone regeneration; Lithium;

    Abstract : The Wnt signaling pathway plays a central role in bone and cartilage embryonic development, processes that are recapitulated during regeneration. Imbalance in such well conserved and complex system often contributes to numerous diseases, whereas controlled modulation of the Wnt signaling activity is an attractive target e.g. READ MORE

  4. 2. Analysis of signaling pathway activity in single cells using the in situ Proximity Ligation Assay

    Author : Linda Arngården; Ola Söderberg; Niclas Karlsson; Uppsala universitet; []
    Keywords : cell signaling; Wnt; Hippo; TGFB; Molekylär medicin; Molecular Medicine;

    Abstract : A cell that senses signals from its environment uses proteins for signal transduction via post translational modifications (PTMs) and protein- protein interactions (PPIs) from cell membrane into the nucleus where genes controlling cell proliferation, differentiation and apoptosis can be turned on or off, i.e. READ MORE

  5. 3. Role of Wnt-5a in breast cancer

    Author : Janna Sand-Dejmek; Malmö Experimentell patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General pathology; signal transduction; metastasis; adhesion; breast cancer; Syk; Wnt-5a; DDR1; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Abstract : Breast cancer is one of the most common cancer forms in the industrialized world. Only in Sweden, nearly 6000 women are diagnosed with breast cancer each year and 1/3 of them eventually succumb to the disease. READ MORE

  6. 4. The Wnt pathway in ventral midbrain dopaminergic differentiation

    Author : Diogo Ribeiro; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson’s disease (PD) is a debilitating neurodegenerative disease in which dopaminergic (DA) neurons in the substantia nigra are lost. Current treatments such as administration of levodopa (L-DOPA) are initially effective but the disease eventually progresses, highlighting the need for a treatment that restores and maintains the otherwise lost functions. READ MORE

  7. 5. Molecular characterization of FOX factors and Wnt signalling interplay in human cancers

    Author : Giulia Pizzolato; Stefan Koch; Åsa Keita; Boudewijn Burgering; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; FOX proteins; Wnt signalling; p53; Tumour biology; Transcription factors; Proteine FOX; Via di segnalazione Wnt; p53; Biologia dei tumori; Fattori di trascrizione;

    Abstract : Wnt/β-catenin signalling, also referred to as canonical Wnt signalling, is a critical regulator of tissue homeostasis and of the differentiation of cells during development. The outcome of canonical Wnt pathway activity is defined by the regulation of target gene transcription, which ultimately determines cell identity and proliferation. READ MORE