Search for dissertations about: "Wnt signaling"

Showing result 11 - 15 of 92 swedish dissertations containing the words Wnt signaling.

  2. 11. On the role of signaling pathways in the pathogenesis of osteoarthritis

    Author : Johan Stenberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoarthritis; Signalling pathways; proteomics; genomics; GDF5; Wnt;

    Abstract : The problem with degenerating cartilage tissues is one of the major causes for disability worldwide. The aetiology of the cartilage degenerating disease osteoarthritis is elusive and considered to be multifactorial. The aim of the present thesis was to find new hypotheses regarding the aetiology of osteoarthritis with focus on signalling pathways. READ MORE

  4. 12. Genomic Profiling, Mutations and Deranged Signaling in Esophageal Cancer and Hereditary Colorectal Cancer

    Author : Anna Isinger Ekstrand; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal cancer; hereditary cancer; HNPCC; copy number analysis; CGH; gene expression; Wnt; PIK3CA; CHEK2; gastric cancer; colorectal cancer;

    Abstract : Esophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. READ MORE

  5. 13. Specification of Dorsal and Intermediate Telencephalic Character

    Author : Matthew Marklund; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; telencephalon; forebrain; dorsoventral patterning; WNT; FGF; RA; retinoid-mediated signaling; development; specification; cortex; striatal; intermediate; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The telencephalon is the most highly evolved region of the vertebrate central nervous system (CNS). The major structures of the telencephalon - the cortex and basal ganglia – derive from the dorsally positioned pallium and the ventrally positioned subpallium, respectively. READ MORE

  6. 14. Wnt signaling in early brain development and disease

    Author : Panagiotis Papachristou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Wnt/Planar Cell Polarity (PCP) signaling is involved in many cellular processes throughout the development of the embryo. These include control of proliferation, differentiation, migration and cell fate decisions. Deregulation of Wnt/PCP signaling can lead to many developmental abnormalities and cancer. READ MORE

  7. 15. Wnt/beta-catenin signaling in midbrain dopaminergic neurons

    Author : Nina Rawal; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dopamine; neuron; development; beta-catenin; Writ; Parkin; Parkinson s disease;

    Abstract : Parkinson's disease (PD) is caused by a progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra. However, the mechanisms underlying the degeneration remain elusive and there is no cure for P1) at present. READ MORE