Search for dissertations about: "Wnt signaling"
Showing result 21 - 25 of 92 swedish dissertations containing the words Wnt signaling.
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21. Early Rostrocaudal Patterning of the CNS
Abstract : The transformation of an initially uniform population of epiblast cells into an intricately complex central nervous system (CNS) is one of the most fascinating processes during embryonic development. Presumptive neural cells are initially specified as cells of forebrain character. READ MORE
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22. WNT signaling in microglia : WNTs as novel regulators of microglia
Abstract : Microglia, the immunocompetent cells of the central nervous system (CNS) and the brain’s own macrophages are the most motile cells in the CNS and those with highest plasticity, as they rapidly move their projections to actively screen their environment for any type of injury. Upon cell damage or infection, microglia respond quickly: they proliferate, change morphology from ramified to amoeboid state to migrate or invade towards the injury, secrete many types of cytokines and chemokines to communicate with other inflammatory cells, and phagocytose cell debris. READ MORE
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23. Genetic Variations in Type 2 Diabetes and Cardiovascular Disease: A Focus on Gene-Lifestyle Interactions and Mendelian Randomization
Abstract : Type 2 diabetes (T2D) and cardiovascular disease (CVD) are highly prevalent complex diseases that result from lifestyle and genetic factors. Gene-lifestyle interactions are also believed to contribute to the etiology of these diseases. READ MORE
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24. Genetic Studies of Alzheimer's Disease
Abstract : Patients with Alzheimer's disease (AD) often have a family history of the disease, implicating genetics as a major risk factor. Three genes are currently known to cause familial early-onset AD (65 years), only the APOE gene has repeatedly been associated to AD, where the ε4 allele increases disease risk and decreases age at onset. READ MORE
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25. Molecular Studies of Diamond-Blackfan Anemia and Congenital Nail Dysplasia
Abstract : The aim of this thesis is to investigate the effect of genetic mutations on the pathophysiology of two human disorders: Diamond-Blackfan Anemia (DBA) and isolated congenital nail dysplasia. The first part of this thesis (Paper I-III) investigates the mechanism associated with DBA. READ MORE