Search for dissertations about: "Wnt"

Showing result 11 - 15 of 149 swedish dissertations containing the word Wnt.

  2. 11. Specification of the lens and olfactory placodes and dorsoventral patterning of the telencephalon

    Author : My Sjödal; Juha Partanen; Umeå universitet; []
    Keywords : telencephalon; olfactory; lens; BMP; RA; FGF; Wnt; development; placode; gradient; chick; nervous system; dorsoventral; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Abstract : The vertebrate nervous system is a highly complex and intriguing structure with diverse functions. To understand the functional nervous system, we first have to be aware of how it is assembled during development. READ MORE

  4. 12. Aniridia-related keratopathy : structural changes, signaling pathways and clinical aspects

    Author : André Vicente; Fatima Pedrosa Domellöf; Berit Byström; Luis Abegão Pinto; Jing-Xia Liu; Anders Ivarsen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aniridia; aniridia-related keratopathy; PAX6; keratoplasty; fetal cornea; Notch1; Wnt; sonic hedgehog; mTOR; keratocyte; oftalmiatrik; ophthalmology;

    Abstract : Aniridia is a congenital autosomal dominant, bilateral, panocular condition, caused by haploinsufficiency of the Pax6 transcription factor. Aniridia-related keratopathy (ARK) significantly affects vision and quality of life in these patients. READ MORE

  5. 13. Gene and protein expression in denervated atrophic and hypertrophic skeletal muscle

    Author : Marlene Norrby; Sven Tågerud; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Skeletal muscle; Denervation; Hypertrophy; Atrophy; Gene expression; Protein expression; Protein phosphorylation; NIFK; Wnt; MK2; Akt signaling;

    Abstract : Following denervation skeletal muscles change their functional and structural properties. Some changes resemble conditions in developing muscles and may be important for reinnervation. Due to inactivity following denervation most skeletal muscles loose muscle mass and become atrophic. READ MORE

  6. 14. On the role of signaling pathways in the pathogenesis of osteoarthritis

    Author : Johan Stenberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoarthritis; Signalling pathways; proteomics; genomics; GDF5; Wnt;

    Abstract : The problem with degenerating cartilage tissues is one of the major causes for disability worldwide. The aetiology of the cartilage degenerating disease osteoarthritis is elusive and considered to be multifactorial. The aim of the present thesis was to find new hypotheses regarding the aetiology of osteoarthritis with focus on signalling pathways. READ MORE

  7. 15. Genomic Profiling, Mutations and Deranged Signaling in Esophageal Cancer and Hereditary Colorectal Cancer

    Author : Anna Isinger Ekstrand; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal cancer; hereditary cancer; HNPCC; copy number analysis; CGH; gene expression; Wnt; PIK3CA; CHEK2; gastric cancer; colorectal cancer;

    Abstract : Esophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. READ MORE