Search for dissertations about: "X-chromosome"

Showing result 1 - 5 of 39 swedish dissertations containing the word X-chromosome.

  1. 1. ENVIRONMENTAL CONTAMINANTS AND SPERM Y:X CHROMOSOME RATIO. Impact of androgen- and dioxin-related effects in vivo and in vitro

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Tarmo Tiido; Lunds universitet.; Lund University.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AR; polymorphisms; Sertoli cell; endocrine disruption; inhibitory cross-talk; Biomedicinska vetenskaper; Biomedical sciences; AHR; sperm Y:X chromosome ratio; sex ratio; POPs; TCDD;

    Abstract : During the last decades, there has been concern that the environmental contaminants, such as POPs, may contribute to sex ratio changes in offspring of exposed populations. Accidental exposure to TCDD has been shown to be associated with fewer sons in men who were exposed in adolescence or earlier in life. READ MORE

  2. 2. Sperm Y:X chromosome ratio and androgen response in men exposed to environmental pollutants

    University dissertation from Institutionen för translationell medicin

    Author : Linus Kvist; Lunds universitet.; Lund University.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The last several decades have seen an increase in male infertility concomitant with a decline in the birth sex ratio. The conditions are believed to be linked to increased exposure to endocrine disrupting chemicals (EDCs), including the persistent organic pollutants or lifestyle factors e.g. smoking. READ MORE

  3. 3. Molecular Analysis of Normal Human Skin and Basal Cell Carcinoma Using Microdissection Based Methods

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Asplund; Uppsala universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; skin; basal cell carcinoma; microdissection; X-chromosome inactivation; Patologi; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi;

    Abstract : The aim of this thesis was to gain further insight into the biology of normal human skin and basal cell carcinoma (BCC). Morphology in combination with microdissection was used as primary tool for sampling. READ MORE

  4. 4. Molecular Pathogenesis of Cervical Carcinoma Analysis of Clonality, HPV16 Sequence Variations and Loss of Heterozygosity

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Xinrong Hu; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cervical carcinoma; CIN; HPV; LOH; X-chromosome inactivation; clonality; molecular pathogenesis; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Pathology; patologi;

    Abstract : A previous model of morphological pathogenesis assumed that cervical carcinoma is of monoclonal origin and progresses through multiple steps from normal epithelium via CINS into invasive carcinomas. The aim of this study was to investigate the molecular mechanism of pathogenesis of cervical neoplasia. READ MORE

  5. 5. Molecular mechanisms in cervical carcinogenesis : Studies of clonality, somatic genetic alterations and human papillomavirus variants in cervical pre-invasive and invasive cancer

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Zhongmin Guo; Uppsala universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cervical cancer; CIN; clonality; X-chromosome inactivation; LOH; HPV; chromosome 3p; chromosome 6; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Pathology; patologi;

    Abstract : Cervical cancer derives from a series of pre-invasive cervical neoplastic lesions termed CIN I-III (Cervical Intraepithelial Neoplasia) via typical multiple-step processes. In contrast to premalignant disorders in other organs, different degrees of CIN possess a distinct biological behaviour where a proportion spontaneously regress or persist, whereas some progress to invasive cancer. READ MORE