Search for dissertations about: "X-chromosome"
Showing result 16 - 20 of 57 swedish dissertations containing the word X-chromosome.
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16. Chromosome-wide gene regulatory mechanisms in Drosophila melanogaster
Abstract : In Drosophila there are two different chromosome-wide targeting systems, the dosage compensation system that equalizes the transcriptional output from X-linked genes between males and females, and the regulation of the 4th chromosome mediated by the POF protein. The best studied of these two mechanisms is the dosage compensation system. READ MORE
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17. Aneuploidy compensatory mechanisms and genome-wide regulation of gene expression in Drosophila melanogaster
Abstract : Stimulation or repression of gene expression by genome-wide regulatory mechanisms is an important epigenetic regulatory function which can act to efficiently regulate larger regions or specific groups of genes, for example by compensating for loss or gain of chromosome copy numbers. In Drosophila melanogaster there are two known chromosome-wide regulatory systems; the MSL complex, which mediates dosage compensation of the single male X-chromosome and POF, which stimulates expression from the heterochromatic 4th chromosome. READ MORE
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18. Genetic, neurodevelopmental and psychiatric studies of Turner syndrome
Abstract : Turner Syndrome (TS) is a genetic condition characterized by the partial or complete loss of one sex chromosome. Associations with neurodevelopmental and psychiatric disorders has been suggested in TS, but findings are inconsistent. READ MORE
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19. Study of DNA methylation in human pancreatic islets
Abstract : Today type 2 diabetes is a common disease with a worldwide prevalence of 8.3%. The disease is characterised by hyperglycaemia which is a result of insufficient insulin secretion from the beta-cells in the pancreatic islets as well as an insulin resistance seen in the target tissues. READ MORE
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20. Laminins in stemness and germ cell development in human
Abstract : Stem cell niches regulate the fine balance between self-renewal and differentiation of various stem cells. Although crucial hallmarks of stem cell niches, such as the mechanical signalling, neural inputs communicating distant cues, the proximity to blood vessels and the structural support by the surrounding basement membrane (BM), have been evaluated in different niches, little much attention has been directed to the specific composition of the BM. READ MORE