Search for dissertations about: "Y. Vladimir Pabón-Martínez"

Found 1 swedish dissertation containing the words Y. Vladimir Pabón-Martínez.

2. 1. Targeting double-stranded DNA with locked nucleic acid-based (LNA) oligonucleotides (ON) and DNA-binding peptide conjugates

   Author : Y Vladimir Pabón-Martínez; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : In this thesis we have studied two different types of molecules that bind to the major groove of the DNA: (i) oligonucleotides (ONs) containing locked nucleic acid (LNA) and in combination with intercalating agents (Twisted Intercalating Nucleic Acid, TINA, and Benzoquinoquinoxaline, BQQ) and (ii) peptides mimicking the leucine zipper transcription factor (GCN4 bZIP TF). Both ONs and peptides bind to the DNA double helix aiming to serve as transcription regulators of disease related genes. READ MORE