Search for dissertations about: "Y. pseudotuberculosis"

Showing result 1 - 5 of 22 swedish dissertations containing the words Y. pseudotuberculosis.

  2. 1. Controlling virulence in Yersinia pseudotuberculosis through accumulation of phosphorylated CpxR

    Author : Edvin Thanikkal; Matthew Francis; Andrew Darwin; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Y. pseudotuberculosis; CpxA; CpxR; invasin; RovA; RovM; T3SS; virulence; transcriptional regulation; molekylärbiologi; Molecular Biology; mikrobiologi; Microbiology;

    Abstract : Like many Gram-negative bacteria, the food-borne pathogen Yersinia pseudotuberculosis harbours different regulatory mechanisms to maintain an intact bacterial envelope especially during exposure to extracytoplasmic stress (ECS). The CpxA-CpxR two component regulatory system is one such ECS-responsive regulatory mechanism. READ MORE

  4. 2. Antiphagocytosis by Yersinia pseudotuberculosis : role of the YopH target proteins

    Author : Ming Yuan; Maria Fallman; Tommy Nilsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular biology; Cas; Fyb; mAbp1; SKAP-HOM; Yersinia pseudotuberculosis; YopH; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The enteropathogenic bacterium Yersinia pseudotuberculosis binds to β1 integrins on a host cell via its surface protein invasin. This event stimulates signal transduction to the actin cytoskeleton of the eukaryotic cell, which allows the cell to engulf the bacterium that is attached to its surface. However, the pathogen Y. READ MORE

  5. 3. YopD translocator function in Yersinia pseudotuberculosis type III secretion

    Author : Tiago R. D. Costa; Matthew S. Francis; William D. Picking; Umeå universitet; []
    Keywords : Y. pseudotuberculosis; T3SS; translocon; YopD; coiled-coil; effector delivery; regulation; virulence; mikrobiologi; Microbiology;

    Abstract : Type III secretion systems (T3SS) are a common feature of Gram-negative bacteria, allowing them to inject anti-host effectors into the interior of infected eukaryotic cells. By this mechanism, these virulence factors help the bacteria to modulate eukaryotic cell function in its favor and subvert host innate immunity. READ MORE

  6. 4. Persistent infection by Yersinia pseudotuberculosis

    Author : Kemal Avican; Maria Fällman; Wyndham W. Lathem; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Persistent infection; RNA-seq; PMNs; Yersinia; Transcriptome; wrba; fnr; rovA; arcA; rfaH; molekylärbiologi; Molecular Biology; Infectious Diseases; infektionssjukdomar; immunologi; Immunology;

    Abstract : Enteropathogenic Yersinia species can infect many mammalian organs such as the small intestine, cecum, Peyer’s patches, liver, spleen, and lung and cause diseases that resemble a typhoid-like syndrome, as seen for other enteropathogens. We found that sublethal infection doses of Y. READ MORE

  7. 5. Controlling substrate export by the Ysc-Yop type III secretion system in Yersinia

    Author : Ayad Amer; Matthew Francis; David L. Gally; Umeå universitet; []
    Keywords : Y. pseudotuberculosis; T3SS; YscX; YopD; assembly; translation control; temporal secretion.; mikrobiologi; Microbiology;

    Abstract : Several pathogenic Gram-negative bacteria invest in sophisticated type III secretion systems (T3SS) to incapacitate their eukaryotic hosts. T3SSs can secrete protein cargo outside the bacterial cell and also target many of them into the eukaryotic cell interior. READ MORE