Search for dissertations about: "Yersinia"

Showing result 26 - 30 of 54 swedish dissertations containing the word Yersinia.

  1. 26. Role of YopE and LcrH in effector translocation, HeLa cell cytotoxicity and virulence

    University dissertation from Umeå : Molekylärbiologi (Teknisk-naturvetenskaplig fakultet)

    Author : Margareta Aili; Umeå universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia pseudotuberculosis; bacterial pathogenesis; YopE; LcrH; virulence; effector translocation; type III secretion; regulation; ODONTOLOGY Cell and molecular biology; ODONTOLOGI Cell- och molekylärbiologi;

    Abstract : In order to establish an extra-cellular infection the gram-negative bacteria Yersinia pseudotuberculosis uses a type III secretion system (T3SS) to translocate a set of anti-host effectors into eukaryotic cells. The toxins disrupt signalling pathways important for phagocytosis, cytokine production and cell survival. READ MORE

  2. 27. Small Molecules as Tools in Biological Chemistry Effects of Synthetic and Natural Products on the Type III Secretion System

    University dissertation from Umeå : Umeå universitet

    Author : Caroline E. Zetterström; Umeå universitet.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Type III secretion; salicylidene acylhydrazide; virulence-blocker; virulence; inhibitor; target identification; neohopeaphenol A; Yersinia pseudotuberculosis; Pseudomonas aeruginosa; Escherichia coli; biologisk kemi; biological chemistry;

    Abstract : The increasing use of antibiotics has led to a huge problem for society, as some bacteria have developed resistance towards many of the antibiotics currently available. To help find solutions to this problem we studied small molecules that inhibit bacterial virulence, the ability to cause disease. READ MORE

  3. 28. Chemical attenuation of bacterial virulence small molecule inhibitors of type III secretion

    University dissertation from Umeå : Kemi

    Author : Anna Kauppi; Umeå universitet.; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; virulence; type III secretion; T3SS inhibitors; Yop; SMD; QSAR; screening; Yersinia pseudotuberculosis; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. READ MORE

  4. 29. Inhibition of phagocyte signaling by the Yersinia virulence protein YopH

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Kerstin Andersson; Linköpings universitet.; Linköpings universitet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Abstract : Yersinia pseudotuberculosis evades the immediate immune defense of a host organism by inhibiting bactericidal functions of phagocytes, including phagocytosis, cytokine release, and the oxidative burst. Consequently, this pathogen can survive and multiply in lymphatic tissues. An ensemble of proteins called Yops are involved in the virulence of Y. READ MORE

  5. 30. Effects of Microparticulate Drug Delivery Systems Tissue Responses and Transcellular Transport

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Eva Ragnarsson; Uppsala universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; microparticles; vaccine; pDNA vaccine; cationic polymer; gene expression analysis DNA array ; Caco-2; follicle-associated epithelium FAE ; M cell; transcytosis; Yersinia pseudotuberculosis; Galenisk farmaci; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci;

    Abstract : Over the past decade, the development of macromolecular drugs based on peptides, proteins and nucleic acids has increased the interest in microparticulate drug delivery, i.e., the delivery of drug systems in the nanometer and micrometer ranges. READ MORE