Search for dissertations about: "YopD"

Showing result 1 - 5 of 13 swedish dissertations containing the word YopD.

2. 1. YopD translocator function in Yersinia pseudotuberculosis type III secretion

   Author : Tiago R. D. Costa; Matthew S. Francis; William D. Picking; Umeå universitet; []
   Keywords : Y. pseudotuberculosis; T3SS; translocon; YopD; coiled-coil; effector delivery; regulation; virulence; mikrobiologi; Microbiology;

   Abstract : Type III secretion systems (T3SS) are a common feature of Gram-negative bacteria, allowing them to inject anti-host effectors into the interior of infected eukaryotic cells. By this mechanism, these virulence factors help the bacteria to modulate eukaryotic cell function in its favor and subvert host innate immunity. READ MORE

4. 2. Delivery of TypeIII Secreted Toxins by Yersinia pseudotuberculosis : the Role of LcrV, YopD, and Free Lipids in the Translocation Process

   Author : Jan Olsson; Hans Wolf-Watz; Ina Attree; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia; T3SS; translocation; YopD; LcrV; YLC; fatty acids.; Molecular biology; Molekylärbiologi;

   Abstract : Bacteria that infect humans and animals face a hard combat with the host´s immune system and in order to establish infection, pathogenic bacteria has evolved mechanisms to avoid being cleared from the host tissue. Many Gram-negatives carry a Type 3 secretion (T3S) system that is used to deliver effector proteins (toxins) into host cells. READ MORE

5. 3. Multiple twists in the molecular tales of YopD and LcrH in type III secretion by Yersinia pseudotuberculosis

   Author : Petra J Edqvist; Matthew Francis; Olaf Schneewind; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia pseudotuberculosis; T3SS; YopD; translocation process; LcrH; class II chaperone; substrate secretion pathway specificity; Molecular biology; Molekylärbiologi;

   Abstract : The type III secretion system (T3SS) is a highly conserved secretion system among Gram negative bacteria that translocates anti-host proteins directly into the infected cells to overcome the host immune system and establish a bacterial infection. Yersinia pseudotuberculosis is one of three pathogenic Yersinia spp. READ MORE

6. 4. Controlling substrate export by the Ysc-Yop type III secretion system in Yersinia

   Author : Ayad Amer; Matthew Francis; David L. Gally; Umeå universitet; []
   Keywords : Y. pseudotuberculosis; T3SS; YscX; YopD; assembly; translation control; temporal secretion.; mikrobiologi; Microbiology;

   Abstract : Several pathogenic Gram-negative bacteria invest in sophisticated type III secretion systems (T3SS) to incapacitate their eukaryotic hosts. T3SSs can secrete protein cargo outside the bacterial cell and also target many of them into the eukaryotic cell interior. READ MORE

7. 5. Studies of protein structure, dynamics and protein-ligand interactions using NMR spectroscopy

   Author : Tobias Tengel; Göran Larsson; Maria Sunnerhagen; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; 19F NMR; 2S albumin; PapD; protein-ligand interaction; structure; TFE; Yersinia; YopD; allergy; amphipathic helix; Ber e 1; Brazil nut; dynamics; FimC; LcrH; NMR screening; Biophysics; Biofysik;

   Abstract : In the first part of the thesis, protein-ligand interactions were investigated using the chaperone LcrH, from Yersinia as target protein. The structure of a peptide encompassing the amphipathic domain (residue 278-300) of the protein YopD from Yersinia was determined by NMR in 40% TFE. READ MORE