Search for dissertations about: "YopE"

Showing result 1 - 5 of 8 swedish dissertations containing the word YopE.

  1. 1. The multifunctional GAP protein YopE of Yersinia is involved in effector translocation control and virulence

    University dissertation from Umeå : Umeå universitet

    Author : Elin Isaksson; Hans Wolf-Watz; Joseph Barbieri; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia; T3SS; YopE; GAP activity; translocation control; virulence; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The Gram-negative bacterium Yersiniapseudotuberculosis employs a type 3 secretion system (T3SS) to establish infections. The T3SS translocates a diverse set of effector proteins directly into the host cells. READ MORE

  2. 2. Role of YopE and LcrH in effector translocation, HeLa cell cytotoxicity and virulence

    University dissertation from Umeå : Molekylärbiologi (Teknisk-naturvetenskaplig fakultet)

    Author : Margareta Aili; Roland Rosqvist; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia pseudotuberculosis; bacterial pathogenesis; YopE; LcrH; virulence; effector translocation; type III secretion; regulation; ODONTOLOGY Cell and molecular biology; ODONTOLOGI Cell- och molekylärbiologi;

    Abstract : In order to establish an extra-cellular infection the gram-negative bacteria Yersinia pseudotuberculosis uses a type III secretion system (T3SS) to translocate a set of anti-host effectors into eukaryotic cells. The toxins disrupt signalling pathways important for phagocytosis, cytokine production and cell survival. READ MORE

  3. 3. Yersinia-phagocyte interactions during early infection

    University dissertation from Umeå : Molekylärbiologi (Teknisk-naturvetenskaplig fakultet)

    Author : Linda Westermark; Maria Fällman; Joan Mecsas; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia; dendritic cell; macrophage; neutrophil; T3SS; Infectious Diseases; infektionssjukdomar;

    Abstract : Pathogenic Gram-negative Yersinia species preferentially target and inactivate phagocytic cells of the innate immune defense by translocation of effector Yersinia outer proteins (Yops) into the cells via a type III secretion system. This indicates that inactivation and avoidance of the early innate immune response is an efficient way for Yersinia species to avoid elimination and to cause diseases ranging from mild gastroenteritis (Y. READ MORE

  4. 4. Host-pathogen interactions during Campylobacter and Yersinia infections

    University dissertation from Umeå : Umeå University

    Author : Nayyer Taheri; Anna Fahlgren; Maria Fällman; Sun Nyunt Wai; Elena Vikström; [2019]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Campylobacter jejuni; Yersinia pseudotuberculosis; OMV; bile; temperature; proteomic;

    Abstract : The innate immune system is known for protecting the host against invading pathogens, for instance enteropathogens infecting the gastrointestinal tract. The production of e.g. antimicrobial peptides, cytokines, and chemokines by innate immune cells and intestinal epithelial cells contribute to bacterial clearance. READ MORE

  5. 5. Chemical attenuation of bacterial virulence small molecule inhibitors of type III secretion

    University dissertation from Umeå : Kemi

    Author : Anna Kauppi; Mikael Elofsson; Anders Karlén; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; virulence; type III secretion; T3SS inhibitors; Yop; SMD; QSAR; screening; Yersinia pseudotuberculosis; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. READ MORE