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Showing result 1 - 5 of 10 swedish dissertations matching the above criteria.

  2. 1. Antiphagocytosis by Yersinia pseudotuberculosis : role of the YopH target proteins

    Author : Ming Yuan; Maria Fallman; Tommy Nilsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular biology; Cas; Fyb; mAbp1; SKAP-HOM; Yersinia pseudotuberculosis; YopH; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The enteropathogenic bacterium Yersinia pseudotuberculosis binds to β1 integrins on a host cell via its surface protein invasin. This event stimulates signal transduction to the actin cytoskeleton of the eukaryotic cell, which allows the cell to engulf the bacterium that is attached to its surface. However, the pathogen Y. READ MORE

  4. 2. Effects of invasin and YopH of Yersinia pseudotuberculosis on host cell signaling

    Author : Anna Gustavsson; Maria Fällman; Arnoud Sonnenberg; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; β1-integrin; Yersinia pseudotuberculosis; Invasin; YopH; Cell-Matrix Adhesion; Filopodia; Cell Spreading; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Integrins are a large family of membrane-spanning heterodimeric (αβ) receptors that bind to ligands on other cells or to extracellular matrix (ECM) proteins. These receptors mediate bidirectional signaling over the cell membrane to induce signaling cascades mediating functions as cell adhesion, spreading and migration. READ MORE

  5. 3. Timing and targeting of Type III secretion translocation of virulence effectors in Yersinia

    Author : Sofie Ekestubbe; Åke Forsberg; Roland Rosqvist; Maria Fällman; Kurt Schesser; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Type III secretion system; virulence; translocation; Yersinia pseudotuberculosis; LcrV; YopN; effector targeting; phagocytosis inhibition; YopH; in vivo infection;

    Abstract : The Type III secretion system (T3SS) is an important virulence mechanism that allows pathogenic bacteria to translocate virulence effectors directly into the cytoplasm of eukaryotic host cells to manipulate the host cells in favor of the pathogen. Enteropathogenic Yersinia pseudotuberculosis use a T3SS to translocate effectors, Yops, that prevent phagocytosis by immune cells, and is largely dependent on it to establish and sustain an infection in the lymphoid tissues of a mammalian host. READ MORE

  6. 4. Inhibition of phagocyte signaling by the Yersinia virulence protein YopH

    Author : Kerstin Andersson; Kerstin Andersson; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Yersinia pseudotuberculosis evades the immediate immune defense of a host organism by inhibiting bactericidal functions of phagocytes, including phagocytosis, cytokine release, and the oxidative burst. Consequently, this pathogen can survive and multiply in lymphatic tissues. An ensemble of proteins called Yops are involved in the virulence of Y. READ MORE

  7. 5. Interactions between Yersinia pseudotuberculosis and host cells - role of invasin and YopH

    Author : Nivia Hamid; Erik Lundgren; Erik Kihlström; Umeå universitet; []
    Keywords : ;

    Abstract : .... READ MORE