Search for dissertations about: "Zohreh Varasteh"
Found 1 swedish dissertation containing the words Zohreh Varasteh.
1. Bombesin Antagonists for Targeting Gastrin-Releasing Peptide Receptor-Positive Tumors Design, Synthesis, Preclinical Evaluation and Optimization of Imaging AgentsUniversity dissertation from Uppsala : Acta Universitatis Upsaliensis
Abstract : This thesis is focused on the development, preclinical evaluation, and optimization of radiotracers for the detection of gastrin-releasing peptide receptor (GRPR)-expressing tumors. The work is divided into three distinct parts: (1) the development of bombesin (BN) antagonist (RM26)-based imaging radiotracers for the detection of GRPR-expressing tumors using different positron emission tomography (PET) and single photon emission computed tomography (SPECT) radionuclides (68Ga, 18F and 111In), (2) the establishment of a method to monitor the ligand-G protein-coupled receptor (GPCR) interaction in real time without requiring purification and stabilization of the receptors, and (3) the evaluation of radiopeptide structure-related factors (length of mini-PEG linker and composition of chelator for metal labeling) affecting the in vitro and in vivo characteristics of RM26-based tracers. READ MORE